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BAY 61-3606  ≥98%

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包装规格：2mg 5mg 10mg 25mg 50mg in glass bottle
产品简介：一种有效的，具有口服活性的，ATP 竞争性的，可逆的选择性 Syk 抑制剂，Ki 为 7.5nM，IC50 为 10nM。
溶解性：溶于DMSO（5 mg/mL 超声，加热）
储备液保存：-80°C, 6 months -20°C, 1 month
靶点：Ki: 7.5 nM (Syk) IC50: 10 nM (Syk)
体外研究：BAY 61-3606 (0.01-10 μM ; 48 hours) significantly reduces the cell viability of SYK-positive SH-SY5Y and SYK-negative SK-N-BE cells in a dose-dependent matter. SH-SY5Y cells expressing high SYK levels are significantly more sensitive to BAY 61-3606 in comparison to SK-N-BEcells expressing very low or no SYK. BAY 61-3606 (0.4 and 0.8 μM; 4 or 24 hours) inhibits SYK activity by reducing ERK1/2 and Akt phosphorylation in neuroblastoma cell SH-SY5Y. BAY 61-3606 (2 μM; 2 hours) induces a large decrease of Syk phosphorylation in K-rn cell lysates.
体内研究：Bay 61-3606 (50 mg/kg; administered twice a week for two weeks by intraperitoneal injection) alone leads to more efficacious reductions than that of TNF-related apoptosis-inducing ligand (TRAIL; 10 mg/kg) alone in MCF-7 tumor xenograft-bearing BALB/c nude mice. Bay 61-3606 administered in TRAIL combination significantly reduces the volume of the xenografted tumor.
保存条件：-20℃
注意事项：1、为了您的安全和健康，请穿实验服并戴一次性手套操作。 2、以上信息仅做参考交流之用。

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