生物试剂
>
生化试剂
>
信号通路
> DJ001
加入收藏 取消收藏

DJ001  ≥98%

促销价¥{{model.attbuying.price}}

市场价¥0.00

累计销量0 累计评价0 人评论

别称 {{model.alias}}
中文名称 {{model.name}}
英文名称 {{model.enname}}
品牌 {{model.brand}}
CAS {{model.cas}}
分子式
分子量 {{model.molecularweight}}
MDL {{model.mdl}}
货号 {{model.procode}}
数量

+ -

件 库存{{model.attbuying.number}}件
立即购买 加入购物车 下载说明书

看了又看
包装规格：5mg in glass bottle
溶解性：溶于DMSO（250 mg/mL 超声）
产品描述：基本信息 产品编号： D10759 产品名称： DJ001 CAS: 2161305-12-8   储存条件 粉末 -20℃ 四年     分子式： C15H12N2O3 溶于液体 -80℃ 六个月 分子量 268.27 -20℃ 一个月 化学名：  (Z)-3-(3-Nitrophenylamino)-1-phenylprop-2-en-1-one;(Z)-3-(3-Nitroanilino)-1-phenylprop-2-en-1-one Solubility (25°C)：   体外:   DMSO 250mg/mL(931.90mM;Need ultrasonic) Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.7276mL 18.6379mL 37.2759mL 5mM 0.7455mL 3.7276mL 7.4552mL 10mM 0.3728mL 1.8638mL 3.7276mL   生物活性 产品描述 一种高度特异性，选择性和非竞争性的蛋白酪氨酸磷酸酶-σ(PTPσ)抑制剂，IC50为1.43μM。 靶点 IC50: 1.43μM (Protein tyrosine phosphatase-σ) 体外研究 DJ001 (5-1000ng/mL; 3-7 days; BM KSL cells) treatment increases the percentages and numbers of BM KSL cells in culture compared with control cultures. DJ001 treatment also significantly increases the numbers of colony forming cells (CFCs) in 3 day culture of BM KSL cells. The BM KSL cells are irradiated with 300 cGy and placed in media (containing 20ng/mL Thrombopoietin, 100ng/mL stem cell factor (SCF), 50ng/mL Flt3 ligand, TSF) with and without 1 μg/mL DJ001 for 3 days. DJ001 treatment increases recovery of BM CFCs and multipotent colony-forming unit–granulocyte erythroid monocyte megakaryocyte (CFU-GEMM) colonies compared with control cultures Cell Viability Assay Cell Line: BM KSL cells Concentration: 5ng/mL, 10ng/mL, 100ng/mL, 1000ng/mL Incubation Time: 3 days or 7 days Result: Increased the percentages and numbers of BM KSL cells. Also significantly increased the numbers of colony forming cells (CFCs) in 3 day culture of BM KSL cells. 体内研究 DJ001 (5 mg/kg; subcutaneous injection; for 24 hours; female C57BL/6 mice) significantly decreases the percentage of apoptotic BM KSL cells in C57BL/6 mice at 24 h following 500 cGy TBI. DJ001 suppresses radiation-induced HSC apoptosis via activation of the RhoGTPase, RAC1, and induction of BCL-XL Animal Model: Female C57BL/6 mice (8-10-week-old) irradiated with total body irradiation (TBI) Dosage: 5 mg/kg Administration: Subcutaneous injection; for 24 hours Result: Significantly decreased the percentage of apoptotic BM KSL cells in C57BL/6 mice at 24 h following 500 cGy TBI.
保存条件：-20℃

猜你喜欢