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UTL-5g  ≥98%

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产品描述：基本信息 产品编号：U10064 产品名称：UTL-5g CAS: 646530-37-2   储存条件 粉末 -20℃ 四年     分子式： C11H8Cl2N2O2 溶于液体 -80℃ 六个月 分子量 271.10 -20℃ 一个月 化学名：      Solubility (25°C)   体外 DMSO ' mg/mL Ethanol   Water   体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.6887mL 18.4434mL 36.8868mL 5mM 0.7377mL 3.6887mL 7.3774mL 10mM 0.3689mL 1.8443mL 3.6887mL   生物活性 产品描述 一种抗炎性 TNF-α 抑制剂，具有化学保护和肝脏放射保护作用。UTL-5g 通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性。 靶点/IC50 TNF Receptor 体外研究 RAW 264.7 macrophages are transfected with the respective reporter assay plasmids, pretreated with UTL-5g at 1, 10 or 50µM for 60 min and then challenged with 100ng/ml LPS. After a 16h incubation,transcription factor activity is measured.Transcription factors that shows a UTL-5g dose-dependent decrease in activity in two experiments are categorized as being disrupted by UTL-5g. 体内研究 UTL-5g (GBL-5g) lowers levels of TGF-β and TNF-α elevated by lung irradiation.UTL-5g (60mg/kg; p.o.; daily for 4 days) shows positive effects in increasing the survival rates and extending the survival times. Animal Model: C57BL/6, male mice (8-10 weeks) Dosage: 15, 30, and 60mg/kg Administration: I.p.; before irradiation, daily x 5 Result: Blood levels of TGF-β were lowered.   Animal Model: BDF1 female mice Dosage: P.o.; daily for 4 days Administration: 60mg/kg (30min before i.p. injection of Cisplatin at 10, 15, and 20mg/kg respectively on Day 0) Result: Increased the survival rate and delayed the time to death for mice treated with 150% of the maximum tolerated dose (MTD) of Cisplatin (15mg/kg). At 200% of the MTD of Cisplatin (20mg/kg), treatment of UTL-5g increased the survival rate and delayed the time to death.
保存条件：-20℃

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