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伊普柳氮  ≥98%

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包装规格：1mg 5mg in glass bottle
产品描述：基本信息 产品编号：I10284 产品名称：Ipsalazide CAS: 82101-17-5 储存条件 粉末 -20℃ 四年 分子式： C16H11N3Na2O6 分子量 387.25 化学名：  (E)-3-(2-(4-((carboxymethyl)carbamoyl)phenyl)hydrazono)-6-oxocyclohexa-1,4-diene-1-carboxylic acid   Solubility (25°C)   体外 DMSO   Ethanol   Water   体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种新的柳氮磺吡啶类似物，旨在释放胃肠道中的 5-氨基水杨酸和无毒载体分子。 靶点/IC50 Autophagy   体外研究 Sulfasalazine exerts beneficial effects in colitis by releasing 5-aminosalicylic acid in the colon, but its use can be limited by side effects. Ipsalazide is designed which the sulfapyridine of sulfasalazine has been replaced by carrier molecules.   体内研究 No deaths or visible abnormalities occurrs within 7 days of a single oral dose of ipsalazide (4g/kg in mice or 2g/kg in rats). No abnormalities were seen at postmortem. The ipsalazide carrier molecule (ABG) is readily absorbed, with nearly half of the dose appearing in the urine. However, around 40% of the ABG was not recovered, and it is possible that this has undergone further metabolism, with loss of the aromatic amine function which is the basis for the colorimetric measurement of ABG.   推荐实验方法(仅供参考) 动物实验:   Animal Administration Rats Maximum single doses administered orally are 2g/kg body weight to 10 male and 10 female Biorex Wistar rats and 4g/kg to 10 male and 10 female Swiss albino mice. The animals are observed for 7 days, any mortalities are recorded, and a full postmortem performed.
保存条件：-20℃

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