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SMN-C3  ≥98%

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包装规格：1mg 5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO（5 mg/mL 超声）
产品描述：基本信息 产品编号：S10772 产品名称：SMN-C3 CAS: 1449597-34-5   储存条件 粉末 -20℃ 四年     分子式： C24H28N6O 溶于液体 -80℃ 六个月 分子量 416.52 -20℃ 一个月 化学名：  2-(4,6-Dimethylpyrazolo(1,5-a)pyrazin-2-yl)-7-(1-ethyl-4-piperidyl)-9-methyl-pyrido(1,2-a)pyrimidin-4-one   Solubility (25°C)   体外 DMSO 5mg/mL (12.00mM; Need ultrasonic) Ethanol   Water   体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.4008mL 12.0042mL 24.0085mL 5mM 0.4802mL 2.4008mL 4.8017mL 10mM 0.2401mL 1.2004mL 2.4008mL   生物活性 产品描述 一种可口服的 SMN2 剪接调节剂，可用于脊椎肌肉萎缩 (SMA) 的研究。 靶点/IC50 SMN 体内研究 At P16, vehicle treated D7 mice are much smaller than heterozygous littermate controls and appear moribund. In contrast, D7 mice treated with the high dose of SMN-C3 show a phenotype similar to that of heterozygous controls. SMN-C3 treatment induces a dose-dependent bodyweight gain in the D7 mice, with some animals showing a body weight that is ~80% that of heterozygous controls. SMN-C3 normalizes the motor behavior of D7 mice, illustrated by the ability of the mice to right themselves as quickly as heterozygous controls and by their level of locomotor activity. Most importantly, whereas vehicletreated mice die within 3 weeks after birth with a median survival of 18 days, SMN-C3 treatment increases survival in a dosedependent manner to a median survival time of 28 days in the low-dose (0.3mg/kg per day) group. In the two higher-dose groups (1 and 3mg/kg per day), ~90% of animals survive beyond P65 when the study is completed.   推荐实验方法(仅供参考) 动物实验： Animal Administration Mice The animals are treated with SMN-C3 at doses of 0.3, 1, and 3mg/kg per day by intraperitoneal injections from P3 through P23 and thereafter at doses of 1, 3, and 10 mg/kg per day, respectively, by oral gavage.
保存条件：-20℃

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