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Emodepside  ≥98%

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包装规格：5mg 10mg 25mg 100mg in glass bottle
溶解性：溶于DMSO（120 mg/mL 超声)
产品描述：基本信息 产品编号：E10322 产品名称：Emodepside CAS: 155030-63-0   储存条件 粉末 -20℃ 四年     分子式： C60H90N6O14 溶于液体 -80℃ 两年 分子量 1119.39 -20℃ 一个月 化学名：  (3S,6R,9S,12R,15S,18R,21S,24R)-3,9,15,21-tetraisobutyl-4,6,10,16,18,22-hexamethyl-12,24-bis(4-morpholinobenzyl)-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclotetracosan-2,5,8,11,14,17,20,23-octaone   Solubility (25°C)   体外 DMSO 100mg/mL (89.33mM) Ethanol 20mg/mL (17.86mM) Water Insoluble 体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 0.8933mL 4.4667mL 8.9334mL 5mM 0.1787mL 0.8933mL 1.7867mL 10mM 0.0893mL 0.4467mL 0.8933mL 50mM 0.0179mL 0.0893mL 0.1787mL   生物活性 产品描述 具有广谱驱虫活性的环庚三烯肽。 靶点/IC50 Ca-dependent SLO-1-like K channels ()   体外研究 Emodepside is a semisynthetic derivative of PF1022A, which contains a morpholine attached in para position at each of both D-phenyllactic acids. Emodepside is efficacious against a variety of gastrointestinal nematodes. Emodepside binds to a presynaptic latrophilin receptor in nematodes. Emodepside produces a slow time-dependent (20 min), 4-aminopyridine sensitive, concentration-dependent hyperpolarization and increase in voltage-activated K currents. Emodepside has an inhibitory effect on spiking. Emodepside significantly inhibits the ryanodine increase in spike frequency between the 20 and 35 min period by 9.8 spikes/min. In the presence of emodepside, highly increased currents are observed without depolarization up to a threshold of 0 mV and without any additional stimuli to artificially increase [Ca 2+]i levels. These novel findings confirm that Slo-1 is a direct target of emodepside.   体内研究 Emodepside interferes with signaling at the neuromuscular junction on the body-wall muscles, pharynx and egg-laying muscles and thus inhibits three important physiological functions: locomotion, feeding and reproduction.
保存条件：-20℃

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