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伐昔洛韦  ≥98%

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包装规格：10mg 50mg 250mg in glass bottle
产品描述：基本信息 产品编号：V10092 产品名称：Valacyclovir CAS: 124832-26-4   储存条件 粉末 -20℃ 四年 分子式： C13H20N6O4 分子量 324.34 化学名：  2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate   Solubility (25°C)   体外 DMSO   Ethanol   Water   体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种口服有效的抗病毒药物，可以抑制单纯疱疹，带状疱疹和疱疹 B。 靶点/IC50 HSV-1 2.9μg/mL (IC50)   体外研究 Valacyclovir (Valaciclovir; VACV) uptake was concentration dependent and saturable with a Michaelis-Menten constant and maximum velocity of 1.64mM and 23.34nmol/mg protein/5 min, respectively. A very similar Km value was obtained in hPEPT1/CHO cells and in rat and rabbit tissues and Caco-2 cells, suggesting that hPEPT1 dominates the intestinal transport properties of VACV in vitro.   体内研究 For treatment of a first episode of genital herpes, a large comparative trial has shown that Valacyclovir (1g twice a day) is as effective as acyclovir (200mg five times a day) when given for 10 days. For treating recurrences, two trials show that valacyclovir is as effective as acyclovir (200mg five times a day) with a treatment period of 5 days. A daily dose of 1g of valacyclovir is as effective as 2g daily. Valacyclovir can be administered once a day. The concentrations of acyclovir in serum and CSF were measured at steady state after 6days of oral treatment with 1,000mg of valacyclovir three times a day. EC50 values of PE and AC in 3T3 cells were 0.02 and 0.01ug/ml, while values in BHK cells were 0.2 and 0.03ug/ml. Treatment of infected immunosuppressed mice and FA and VA (b.i.d., 5.5days) reduced the proportion with erythema from 100% to 24% and 38%, and eliminated ear paralysis, ear lesions (vesicles, etc) and death. Virus was absent from ear and brainstem by day 6, but reappeared after discontinuation in mice treated with VA.
保存条件：-20℃

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