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Merimepodib  98.6319%

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包装规格：2mg 5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO（≥ 31 mg/mL)
产品描述：基本信息 产品编号：M10626 产品名称：Merimepodib CAS: 198821-22-6   储存条件 粉末 -20℃ 四年     分子式： C23H24N4O6 溶于液体 -80℃ 两年 分子量 452.46 -20℃ 一个月 化学名：  [(3S)-oxolan-3-yl] N-[[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]methyl]carbamate   Solubility (25°C)   体外 DMSO 90mg/mL (198.91mM) Ethanol Insoluble Water Insoluble 体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.2101mL 11.0507mL 22.1014mL 5mM 0.4420mL 2.2101mL 4.4203mL 10mM 0.2210mL 1.1051mL 2.2101mL 50mM 0.0442mL 0.2210mL 0.4420mL   生物活性 产品描述 非竞争型，有口服活性的肌苷一磷酸脱氢酶抑制剂，具有广谱抗病毒活性。 靶点/IC50 IMPDH()   体外研究 VX-497 has antiproliferative effect on lymphoid and keratinocyte cells. The antiproliferative effect of VX-497 in cells is reversed within 48h of its removal. VX-497 has intermediate antiviral activity against a second group of viruses, which includes HSV-1, parainfluenza-3 virus, BVDV, VEEV, and dengue virus, with IC50s ranging from 6 to 19μM. VX-497 is 100-fold more potent, with an IC50 of 380nM and a corresponding CC50 of 5.2μM, for a therapeutic index of 14. The antiviral activity of VX-497 in HepG2.2.2.15 cells is reversed threefold by the addition of guanosine.   体内研究 Oral administration of VX-497 inhibits the primary IgM antibody response in a dose-dependent manner, with an ED50 value of appr 30-35mg/kg in mice. Single daily dosing of VX-497 is observed to be as effective as twice-daily dosing in this model of immune activation. GVHD developed in the vehicle-treated allografted F1 mice and treatment with VX-497 improved all manifestations of the disease significantly. The 2.9-fold increase in spleen weight in allografted animals is reduced to a 1.6- fold increase in the VX-497-treated mice. Serum IFN-gamma levels are increased 54-fold in the vehicle group while there is a 7.4-fold increase in VX-497-treated animals.   推荐实验方法(仅供参考) 细胞实验:   Cell Assay The murine fibroblast L929 cell line is cultured in Eagle minimal essential medium supplemented with 10% fetal bovine serum, nonessential amino acids, 50 U of penicillin per mL, 50μg of streptomycin per mL, and 2mM l-glutamine. EMCV is infected at 500 PFU/107 L929 cells. Cells are left untreated or are treated with different concentrations of murine IFN-α alone, VX-497 alone, or combinations thereof.
保存条件：-20℃

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