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包装规格：5mg in glass bottle
溶解性：溶于DMSO（250 mg/mL 超声)
产品描述：基本信息 产品编号：F10211 产品名称：Furaprofen CAS: 67700-30-5   储存条件 粉末 -20℃ 四年     分子式： C17H14O3 溶于液体 -80℃ 六个月 分子量 266.29 -20℃ 一个月 化学名：  7-Benzofuranacetic acid, alpha-methyl-3-phenyl-, (+-)-   Solubility (25°C)   体外 DMSO 200mg/mL (751.06mM; Need ultrasonic) Ethanol   Water   体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.7553mL 18.7765mL 37.5530mL 5mM 0.7511mL 3.7553mL 7.5106mL 10mM 0.3755mL 1.8777mL 3.7553mL   生物活性 产品描述 一种有效的 HCV 复制抑制剂。作用于 HCV 基因型 1a 和 1b 复制子时 EC50 约为 30nM，作用于基因型 2a 复制子时 EC50 约为 1000nM。 靶点/IC50 HCV genotype 1a and 1b replicons EC50: ~30nM  HCV genotype 2a replicon ~1000nM   体外研究 Furaprofen (R803) is potent and highly specific for HCV replication. The antiviral activity of Furaprofen has been determined by a reporter replicon assay with multiple repeats to be 29.88±8.05nM, an ~3-fold improvement over the activity of the parent compound, R706. The potency of Furaprofen against the replicon is also confirmed by both Western blotting and TaqMan RT-PCR to be about 37nM and 54.67±4.11nM, respectively. To assess the general effect of Furaprofen on cell proliferation, a panel of primary cells and transformed human cell lines are treated with increasing doses of Furaprofen for 48 h, and the effect on cell proliferation is measured by an MTS-based cell viability assay. The the concentration that caused a 50% reduction in cell numbers in the absence of virus infection (CC50) of Furaprofen is found to range from 2μM to ≥10μM,depending on the cell type and proliferation status.   推荐实验方法(仅供参考) 细胞实验:   Cell Assay Replicon 9-13 cells are plated onto 6-well plates 24 h prior to the treatment. Serial dilutions of Furaprofen are made in a mixture containing 90% of the culture medium, 7.2% 1× PBS, 1.8% methanol, 1% DMSO, 20μM RBV, and varying concentrations of IFN-α for a fixed-ratio dose-response study. The cells are treated with the designated combinations of Furaprofen (0 to 80 nM concentrations) and IFN-α (0 to 4 IU/mL) plus 20μM RBV for 72 h; then they are washed with PBS,lysed in SDS loading buffer, and analyzed by Western blotting .
保存条件：-20℃

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