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Ribocil-C  ≥98%

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包装规格：5mg 10mg in glass bottle
溶解性：溶于DMSO（110 mg/mL 超声)
产品描述：基本信息 产品编号：R10191 产品名称：Ribocil-C CAS: 1825355-56-3   储存条件 粉末 -20℃ 四年     分子式： C21H21N7Os 溶于液体 -80℃ 六个月 分子量 419.50 -20℃ 一个月 化学名：  2-[(3S)-1-[[1-(2-Pyrimidinyl)-1H-imidazol-4-yl]methyl]-3-piperidinyl]-6-(2-thienyl)-4(3H)-pyrimidinone   Solubility (25°C)   体外 DMSO 100mg/mL (238.38mM) Ethanol   Water   体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.3838mL 11.9190mL 23.8379mL 5mM 0.4768mL 2.3838mL 4.7676mL 10mM 0.2384mL 1.1919mL 2.3838mL   生物活性 产品描述 一种高度选择性的细菌核黄素核糖开关抑制剂。 靶点/IC50 Bacterial riboflavin riboswitches   体外研究 Ribocil-C is a highly selective inhibitor of the flavin mononucleotide (FMN) riboswitch that controls expression of de novo riboflavin (RF, vitamin B2) biosynthesis in Escherichia coli. Ribocil-C specifically inhibits dual FMN riboswitches, separately controlling RF biosynthesis and uptake processes essential for Staphylococcus aureus growth and pathogenesis. Ribocil-C is a small-molecule synthetic mimic of FMN that binds the FMN riboswitch of multiple GN bacteria, including Escherichia coli,Pseudomonas aeruginosa, and Acinetobacter baumannii, to inhibit ribB expression, RF synthesis, and consequently arrest bacterial growth.   体内研究 Higher dose Ribocil-C treatment groups (60 and 120mg kg21 ribocil-C) demonstrate a dose-dependent reduction in bacterial burden of 1.87 and 3.29 log10[CFU per g spleen] reduction respectively versus shamtreated mice, without mortality or gross effects of toxicity observed.   推荐实验方法(仅供参考) 细胞实验:   Animal Administration DBA/2J mice are infected by intraperitoneal injectionwith Escherichia coli strain MB5746 (5×104 CFU per mouse) and treated by subcutaneous injection with Ribocil-C (30, 60, 120mg/kg) or ciprofloxacin (0.5mg/kg) three times over a 24 h infection period. Spleens are aseptically collected from five mice per group and the reduction of log[CFU per g spleen tissue] is calculated on the basis of bacterial burden in spleens of the vehicle-treated (10% DMSO) control group.
保存条件：-20℃

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