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Neticonazole  ≥98%

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包装规格：25mg 50mg 100mg 250mg in glass bottle
溶解性：溶于DMSO（250 mg/mL 超声)
产品描述：基本信息 产品编号：N10412 产品名称：Neticonazole CAS: 130726-68-0   储存条件 粉末 -20℃ 四年     分子式： C17H22N2Os 溶于液体 -80℃ 两年 分子量 302.43 -20℃ 一个月 化学名：  1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole   Solubility (25°C)   体外 DMSO 60mg/mL (198.39mM) Ethanol 60mg/mL (198.39mM) Water 60mg/mL (198.39mM) 体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.3066mL 16.5328mL 33.0655mL 5mM 0.6613mL 3.3066mL 6.6131mL 10mM 0.3307mL 1.6533mL 3.3066mL 50mM 0.0661mL 0.3307mL 0.6613mL   生物活性 产品描述 一种咪唑衍生物，也是一种有效且长效的抗真菌剂,具有抗感染和抗癌作用。 靶点/IC50 exosome ()   体外研究 Neticonazole (10µM; 48hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.Neticonazole (0-10µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.Neticonazole is also an orally active exosome biogenesis and secretion inhibitor. Cell Line: C4-2B cells Concentration: 10µM Incubation Time: 48hours Result: Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels.   体内研究 Neticonazole (1-100ng/kg; oral gavage; daily; for 15days; male C57BL/6mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells. Animal Model: Male C57BL/6mice (8weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells Dosage: 1ng/kg, 10ng/kg and 100ng/kg Dosage: Oral gavage; daily; for 15days Result: Significantly improved the survival of IDB mice with CRC xenograft tumors.
保存条件：-20℃

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