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羟基伊曲康唑  99.87%

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包装规格：1mg 5m 10mg 25mg 50mg in glass bottle
溶解性：溶于DMSO（100 mg/mL 超声)
产品描述：基本信息 产品编号：H10276 产品名称：Hydroxy Itraconazole CAS: 112559-91-8   储存条件 粉末 2-8℃（避光） 四年 分子式： C35H38Cl2N8O5 溶于液体 -80℃（避光） 六个月 分子量 721.63 -20℃（避光） 一个月 化学名：  4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3-hydroxybutan-2-yl)-1,2,4-triazol-3-one   Solubility (25°C)   体外 DMSO 100mg/mL (138.58mM Need ultrasonic) Ethanol   Water < 0.1mg/mL 体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 1.3858mL 6.9288mL 13.8575mL 5mM 0.2772mL 1.3858mL 2.7715mL 10mM 0.1386mL 0.6929mL 1.3858mL   生物活性 产品描述 一种三唑类抗真菌剂 靶点/IC50 Antifungal   体外研究 Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ).Although Hydroxy Itraconazole is also reported to have antifungal activity in vitro, its pharmacokinetics in humans has been studied less than that of ITZ. ITZ and Hydroxy Itraconazole have a triazole ring and inhibit CYP3A. Their half-lives can be extended by 26-60% with repeated administration compared to single administration.   体内研究 The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view.
保存条件：2-8℃ 避光

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