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奥美拉唑钠 促销  ≥98%

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包装规格：5g 25g 100g in poly bottle
产品描述：基本信息 产品编号： O10163  产品名称： Omeprazole Sodium CAS: 95510-70-6   储存条件 粉末 2-8℃ 四年     分子式： C17H19N3NaO3S 溶于液体 -80℃ 6个月 分子量： 367.40 -20℃ 1个月 化学名：  1H-Benzimidazole,6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-,sodium salt(1:1) Solubility (25°C)：   体外:   DMSO 73mg/mL (198.69mM) Ethanol 73mg/mL (198.69mM) Water 73mg/mL (198.69mM) 体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.7218mL 13.6091mL 27.2183mL 5mM 0.5444mL 2.7218mL 5.4437mL 10mM 0.2722mL 1.3609mL 2.7218mL   生物活性 产品描述 一种质子泵(proton pump)抑制剂。 靶点 Proton Pump Autophagy Bacterial Phospholipase   体外研究 Omeprazole (H 16868) is a proton pump inhibitor used in the treatment of dyspepsia,peptic ulcer disease,gastroesophageal reflux disease,laryngopharyngeal reflux,and Zollinger-Ellison syndrome.Omeprazole (H 16868) virtually eliminated intragastric acidity in all patients:the median 24 hour intragastric pH rose from 1.4 to 5.3 and the mean hourly hydrogen ion activity fell from 38.50 to 1.95 mmol(mEq)/1 (p less than 0.001).This inhibition of 24 hour intragastric acidity is more profound than that previously reported with either cimetidine 1g daily or ranitidine 300mg daily.The pharmacokinetics of omeprazole were studied in a group of healthy male subjects after single and repeated oral doses of 30 and 60mg.Absorption of Omeprazole (H 16868) from its enteric-coated formulation was unpredictable.There was a highly significant increase in the area under the plasma concentration time curve (AUC) after repeated dosing.Omeprazole (H 16868) increases its own relative availability following repeated dosing.This may be due to inhibition of gastric acid secretion by omeprazole which is an acid-labile compound.Omeprazole sodium is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
保存条件：2-8℃

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