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包装规格：1g 5g 25g 100g in glass bottle
溶解性：溶于DMSO（≥ 100 mg/mL）
产品描述：基本信息 产品编号：T10512 产品名称：Terbinafine CAS: 91161-71-6   储存条件 粉末 -20℃ 四年     分子式： C21H25N 溶于液体 -80℃ 两年 分子量 291.43 -20℃ 一个月 化学名：  (E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine   Solubility (25°C)   体外 DMSO 58mg/mL (199.01mM) Ethanol 58mg/mL (199.01mM) Water Insoluble 体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.4314mL 17.1568mL 34.3136mL 5mM 0.6863mL 3.4314mL 6.8627mL 10mM 0.3431mL 1.7157mL 3.4314mL 50mM 0.0686mL 0.3431mL 0.6863mL   生物活性 产品描述 一种具有抗真菌感染活性的化合物，是念珠菌属的角鲨烯环氧化酶有效的非竞争性抑制剂。 靶点/IC50 squalene epoxidase   体外研究 Terbinafine has a primary fungicidal action in vitro against most fungal pathogens, including dermatophytes, and dimorphic and filamentous fungi. Terbinafine specifically inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation.The treated fungal cells rapidly accumulate tlic intermediate squalene and become deficient in the end-product of the pathway, ergosterol.   体内研究 Terbinafine is not only active after topical application but is very effective in experimental dermatophytoses following oral administration. In fungi infected guinea-pigs, the skin temperature dropps dramatically after the fourth treatment of terbinafine.       推荐实验方法(仅供参考) 动物实验:   Animal Administration Guinea-pigs: The backs (lumbar regions) of guinea-pigs, which have been mechanically depilated, are infected with 0.1mL Sabouraud's dextrose 2% broth containing 106 c.f.u. of Truhophyton mentagrophytes. The treatments commence 48h postinoculation. The test compounds (Terbinafine) are suspended in 2% tylose and Tween 80 and administered via a stomach tube once daily on 9 consecutive days, or dissolved in a mixture of polyethylene glycol 400 and etbanol and spread on the infected part ot the body in a volume of 0.4mL with a Hrigalski spatula once daily for 1-7 consecutive days .
保存条件：-20℃

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