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氟环戊烯基胞嘧啶  97%

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产品描述：一种新型胞苷类似物，在多种癌细胞株中证明有抗癌活性。RX-3117 is an orally available and potent DNA synthesis inhibitor with potential antineoplastic activity. Upon adinistration, the cytidine analogue RX-3117 is taen up by cells through a carrier-ediated transporter, phosphorylated by uridine cytidine inase (UC) and then further phosphorylated to its diphosphate (RX-DP) and triphosphate fors (RX-TP). The triphosphate for is incorporated into RNA and inhibits RNA synthesis. The diphosphate RX-DP is reduced by ribonucleotide reductase (RR) to dRX-DP; its triphosphate for (dRX-TP) is incorporated into DNA. In addition, RX-3117 also inhibits DNA ethyltransferase 1 (DNT1).
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