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CHIR 98014  ≥98%

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包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO(0.5mg/mL 加热）
产品描述：一种有效的细胞通透的GSK-3抑制剂，可抑制GSK-3α和GSK-3β的活性。CHIR98014 is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50 = 0.65 and 0.58 nM, respectively). It is inactive against a series of other serine/threonine or tyrosine kinases. Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50 = 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals. CHIR98014 also reduces tau phosphorylation in rat brains and supports Wnt signaling during osteogenesis.
保存条件：-20℃

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