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TPI-1  ≥98%

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包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO(50mg/ml超声)
产品描述：一种SHP-1的抑制剂；抑制重组SHP-1的IC50值为40nM。TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor. TPI-1 selectively increased SHP-1 phospho-substrates (pLck-pY394, pZap70, and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP-2 or CD45, respectively. TPI-1 induced mouse splenic-IFN-gamma(+) cells in vitro, approximately 58-fold more effective than sodium stibogluconate, and increased mouse splenic-pLck-pY394 and -IFN-gamma(+) cells in vivo.
保存条件：-20℃

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