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Indisulam  ≥98%

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包装规格：5mg 10mg 25mg 50mg in glass bottle
溶解性：溶于DMSO(20mg/ml 超声)
产品描述：一种碳酸酐酶抑制剂，具有抗癌活性。Indisulam(E7070)是细胞周期G1期的靶向化合物。Indisulam(E7070)通过抑制CDK2和周期蛋白E的激活，引起G1/S转化被阻滞。Indisulam(E7070)通过募集DCAF15诱导RBM39降解来靶向剪接。Indisulam, also known as E7070, is a carbonic anhydrase inhbitor, is also a novel synthetic sulfonamide that targets the G1 phase of the cell cycle.. The potential antitumor activity of Indisulam was discovered through optimization of the structure-activity relationships of a series of sulfonamide structures. Indisulam causes a blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 and cyclin E. Preclinical studies with Indisulam showed activity in multiple tumor types, most prominently in colon and lung cancer.
保存条件：-20℃

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