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Sorbinil  ≥98%

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包装规格：5mg in glass bottle
溶解性：溶于DMSO(＞20mg/mL）
产品描述：一种醛糖还原酶抑制剂(ARI)。Sorbinil可用于糖尿病和糖尿病并发症方的研究，降低AR活性和抑制多元醇途径，发现它比人类使用的其它ARI更安全。Sorbinil, also known as CP-45634, is an aldose reductase inhibitor potentially for the treatment of diabetes. Aldose reductase is an enzyme present in lens and brain that gets rid of excess glucose by converting it to sorbitol. Sorbitol accumulation can lead to the development of cataracts in the lens and neuropathy in peripheral nerves. Sorbinil has been shown to inhibit aldose reductase in human brain and placenta and calf and rat lens. Sorbinil reduced sorbitol accummulation in rat lens and sciatic nerve of diabetic rats orally administered 0.25mg/kg sorbinil.
保存条件：-20℃

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