生物试剂
>
生化试剂
>
信号通路
> NCGC00244536
加入收藏 取消收藏

NCGC00244536  ≥98%

促销价¥{{model.attbuying.price}}

市场价¥0.00

累计销量0 累计评价0 人评论

别称 {{model.alias}}
中文名称 {{model.name}}
英文名称 {{model.enname}}
品牌 {{model.brand}}
CAS {{model.cas}}
分子式
分子量 {{model.molecularweight}}
MDL {{model.mdl}}
货号 {{model.procode}}
数量

+ -

件 库存{{model.attbuying.number}}件
立即购买 加入购物车 下载说明书

看了又看
包装规格：1mg 5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO（36.67mg/mL 超声）
产品描述：基本信息 产品编号：N10664 产品名称：NCGC00244536 CAS: 2003260-55-5   储存条件 粉末 -20℃ 四年     分子式： C25H22N2O2 溶于液体 -80℃ 六个月 分子量： 382.45 -20℃ 一个月 化学名：      Solubility (25°C)   体外 DMSO 76mg/mL (198.71mM) Ethanol 1.5mg/mL (3.92mM) Water Insoluble 体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.6147mL 13.0736mL 26.1472mL 5mM 0.5229mL 2.6147mL 5.2294mL 10mM 0.2615mL 1.3074mL 2.6147mL 50mM 0.0523mL 0.2615mL 0.5229mL   生物活性 产品描述 一种高效的 KDM4B 抑制剂，IC50 值为10nM。 靶点/IC50 KDM4 10nM   体外研究 NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC50=40nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4. NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC50s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth.NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC50s. 体内研究 Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis.   推荐实验方法(仅供参考) 细胞实验:   LNCaP cells are treated with 0.1, 0.2, 1, 2.5, 5, 20μM of NCGC00244536. Cell viability is measured using the MTT assay.   动物实验:   Mouse:For xenograft animal model, PC3 cell suspension is injected into 4-6 weeks old severe combined immunodeficient (SCID) mice. When tumors become palpable, animals are randomly grouped for drug treatment. Alzet osmotic minipump containing NCGC00244536 (20mg/kg)is subcutaneously inserted into each animal, which allowed continuous drug delivery to the tumor site for up to 5 days. Tumor volume is recorded every other days and calculated by using the ellipsoid formula.
保存条件：-20℃

猜你喜欢