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盐酸舒必利  ≥98%

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包装规格：5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于水（50 mg/mL 超声），溶于DMSO（50 mg/mL 超声） -20°C 5mg in glass bottle
产品描述：基本信息 产品编号： S10860 产品名称： Sultopride hydrochloride CAS: 23694-17-9   储存条件 粉末 -20℃ 四年     分子式： C17H27ClN2O4S 溶于液体 -80℃ 6个月 分子量： 390.93 -20℃ 1个月 化学名：  N-[(1-乙基-2-吡咯烷基)甲基]-5-(乙基磺酰)-2-甲氧基苯甲酰胺盐酸盐  LIN-1418 hydrochloride Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.5580mL 12.7900mL 25.5800mL 5mM 0.5116mL 2.5580mL 5.1160mL 10mM 0.2558mL 1.2790mL 2.5580mL   生物活性 产品描述 一种多巴胺 D2 受体的选择性拮抗剂。 靶点 Dopamine D2 receptor 体内研究 Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective antagonist of dopamine D2 receptor.DOPAC and HVA levels in the striatum,the nucleus accumbens and the medial prefrontal cortex are higher in the rats treated with Sultopride hydrochloride and sulpiride than those of the controls. In the striatum,DOPAC and HVA levels are higher in the Sultopride hydrochloride-treated rats than the sulpiride-treated rats (p<0.05).In the nucleus accumbens,DOPAC levels are higher in the Sultopride hydrochloride-treated rats than sulpiride treated rats (p<0.05).In the Sultopride hydrochloride-treated rats,DOPAC and HVA levels are higher in the striatum or in the nucleus accumbens than in the medial prefrontal cortex (p<0.05).   推荐实验方法(仅供参考) 动物实验:   Thirty-six male Sprague-Dawley rats weighing 180 to 220g are used in this study.The rats are divided into three groups of 6 each.One group is intraperitoneally injected with Sultopride hydrochloride (100mg/kg body weight), the second group with sulphide (100mg/kg body weight),and the third group with normal saline.One hundred minutes after the initial treatments,apomorphine (0.1mg/kg body weight,dissolved in saline ad libitum) is administered subcutaneously to the three groups,and 20 minutes later the rats are sacrificed.The third group serves as controls.
保存条件：-20℃

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