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Quinpirole Hydrochloride  ≥98%

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包装规格：5mg in glass bottle
溶解性：溶于水（7mg/mL）,溶于DMSO（27.78mg/mL 超声）
产品描述：基本信息 产品编号： Q10048 产品名称： Quinpirole Hydrochloride CAS: 85798-08-9   储存条件 粉末 -20℃ 四年     分子式： C13H21N3.HCl 溶于液体 -80℃ 6个月 分子量： 255.79 -20℃ 1个月 化学名：  (-)-LY 171555;trans-(–)-(4aR)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline monohydrochloride, (–)-Quinpirole monohydrochloride Solubility (25°C)：   体外:   DMSO 25mg/mL (97.7364mM; Need ultrasonic) Ethanol   Water 50mg/mL (195.47mM; Need ultrasonic) 体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.7919mL 13.9595 mL 27.9189 mL 5mM 0.7819mL 3.9095 mL 7.8189 mL 10mM 3.9095mL 19.5473 mL 39.0946 mL   生物活性 产品描述 一种具有高亲和力的 dopamine D2/D3 受体的激动剂。 靶点 Dopamine D2/D3 receptor   体外研究 DA content is left brain biased across groups,and although this asymmetry appears greater in saline controls than all drugtreated groups, there is not a significant interaction between Side and Group.When each side is considered separately it can be seen that in the left brain structure,DA levels progressively decrease with chronic quinpirole treatment,with the QQ rats differing significantly from saline controls.In contrast,right cortical DA levels are only altered significantly (increased) by acute Quinpirole.It can be found that DOPAC levels are also left brain biased across groups.However,no significant Group or interaction effects are found.Rats receiving acute Quinpirole show a selective increase in DA content and decrease in turnover ratio, relative toeither saline controls or the QS group.Sensitized (QQ) rats however, have elevated DOPAC levels in comparison to the acute quinpirole group.In striatum as well,all three measures of DA function differed significantly across groups (DA,F3,33=6.27,P=0.0020;DOPAC, F3,33=7.98,P=0.0004;turnover ratio,F3,33=16.85,P<0.0001).In the acute quinpirole rats,both DOPAC and turnover ratio are significantly reduced relative to all other groups. In QQ rats, DOPAC levels are ignificantly greater than all other groups, while for turnover ratio, both chronic quinpirole groups were increased compared to both chronic saline groups.   推荐实验方法(仅供参考) 动物实验:   Rat 36 male Long-Evans rats are injected daily for 12 days with either saline or Quinpirole (Hydrochloride) (quinpirole HCl:0.5mg/kg,s.c.,n=18/condition),and placed immediately in Omnitech activity monitors (60×60×40 cm) for 90 min.On the final test day, half the rats in each chronic condition received saline and half Quinpirole (n=9/group).The four groups therefore represented saline controls (SS),acute Quinpirole (SQ),sensitized Quinpirole (no drug)(QS) and sensitized Quinpirole (drug) (QQ).30 min after the final injection,each rat is removed from the activity monitors to a nearby room and killed immediately by decapitation.This time point is chosen to dissociate the behavioural effects of quinpirole between groups,since acute quinpirole produces inhibition of activity at this time, while chronic quinpirole is associated with pronounced hyperlocomotion at 30 min.
保存条件：-20℃

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