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Monastrol  ≥98%

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包装规格：25mg 50mg 100mg 1g in glass bottle
溶解性：溶于DMSO（≥ 33 mg/mL）
产品描述：基本信息 产品编号：M10784 产品名称：Monastrol CAS: 329689-23-8   储存条件 粉末 -20℃ 四年     分子式： C14H16N2O3S 溶于液体 -80℃ 六个月 分子量： 292.35 -20℃ 一个月 化学名：      Solubility (25°C)   体外 DMSO 58mg/mL (198.39mM) Ethanol 58mg/mL (198.39mM) Water Insoluble 体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.4206mL 17.1028mL 34.2056mL 5mM 0.6841mL 3.4206mL 6.8411mL 10mM 0.3421mL 1.7103mL 3.4206mL 50mM 0.0684mL 0.3421mL 0.6841mL   生物活性 产品描述 一种具有高效性和细胞渗透性的有丝分裂驱动蛋白 Eg5 的抑制剂，IC50 值为 14μM。 靶点/IC50 KIF11(Eg5)(Cell-based assay) 14μM   体外研究 Monastrol is a small, cell-permeable molecule that arrests cells in mitosis by specifically inhibiting Eg5, a member of the Kinesin-5 family. Monastrol treatment of dividing cells results in spindle collapse and cell cycle arrest with a monoastral spindle, which is similar to the phenotype observed when Eg5 is inhibited by anti-Eg5 antibodies. Monastrol is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cell lines. Monastrol treatment can decrease cell viability in MCF-7 tumor cells. Real-time cell growth kinetic analysis showed a decrease in the proliferation of MCF-7 cells exposed to monastrol.   推荐实验方法(仅供参考) 细胞实验:   The cytotoxicity assay is performed with MTT. Cells are seeded in 96-well culture plates (5000 cells/well) and incubated for 24h for stabilization. After this period, the following treatments are administered for 24 and 48h: vehicle control (0.5 % DMSO); 1μM doxorubicin and monastrol at 5,25, 50, 75, and 100μM. After each time of treatment, the medium is withdrawn,serum-free media containing 0.5mg/mL MTT salt is added and incubated for 4h, and formazan crystal products are diluted.
保存条件：-20℃

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