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Mycro 3  ≥98%

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包装规格：2mg 5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO（≥ 100 mg/mL）
产品描述：基本信息 产品编号：M10814 产品名称：Mycro 3 CAS: 944547-46-0   储存条件 粉末 -20℃ 四年     分子式： C24H17ClF2N6O4 溶于液体 -80℃ 六个月 分子量 526.88 -20℃ 一个月 化学名：      Solubility (25°C)   体外 DMSO 100mg/mL (189.79mM) Ethanol Insoluble Water Insoluble 体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 1.8980mL 9.4898mL 18.9797mL 5mM 0.3796mL 1.8980mL 3.7959mL 10mM 0.1898mL 0.9490mL 1.8980mL 50mM 0.0380mL 0.1898mL 0.3796mL   生物活性 产品描述 一种有效的选择 Myc-Max 二聚化抑制剂。Mycro 3 可用于胰腺癌的研究。 靶点/IC50 Myc-MAX dimerization 体外研究 Mycro 3 is a potent and selective c-Myc inhibitor in whole cell assays, with weak inhibitory activity against Activator protein 1 (AP-1). Mycro 3 has a superior specificity  profile to its predecessors.Mycro 3 inhibits the interaction between c-Myc and Max.Mycro 3 has high selectivity and inhibits c-Myc/Max dimerization and conjugation with DNA. Mycro 3 exhibits an excellent specificity with IC50s of 0.25 and 9.0 µM for cells with intact Myc alleles and Myc-null cells,respectively. 体内研究 Mycro 3 (100mg/kg; oral administration; daily for two months) induces marked shrinkage of pancreatic ductal adenocarcinoma (PDA), increases cancer cell apoptosis, and reduces cell proliferation. Tumor growth is also drastically attenuated in Mycro 3-treated NOD/SCID mice carrying orthotopic or heterotopic xenografts of human pancreatic cancer cells. Animal Model: Moribund Pdx1-cre/KRAS* mice bearing pancreatic ductal adenocarcinoma (PDA) Dosage: 100mg/kg Administration: Oral administration; daily for two months Result: Increased survival time. Mycro 3 administration was discontinued after two months, the mouse survived for an additional month.
保存条件：-20℃

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