生物试剂
>
生化试剂
>
信号通路
> 土曲霉酮
加入收藏 取消收藏

土曲霉酮  ≥98%

促销价¥{{model.attbuying.price}}

市场价¥0.00

累计销量0 累计评价0 人评论

别称 {{model.alias}}
中文名称 {{model.name}}
英文名称 {{model.enname}}
品牌 {{model.brand}}
CAS {{model.cas}}
分子式
分子量 {{model.molecularweight}}
MDL {{model.mdl}}
货号 {{model.procode}}
数量

+ -

件 库存{{model.attbuying.number}}件
立即购买 加入购物车 下载说明书

看了又看
包装规格：2.5mg 10mg 25mg in glass bottle
产品描述：基本信息 产品编号：T10737  产品名称：Terrein CAS: 582-46-7   储存条件 粉末 -20℃ 四年 分子式： C8H10O3 溶于液体 -80℃ 两年 分子量 154.16     化学名：      Solubility (25°C)   体外 DMSO   Ethanol   Water   体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种黑色素生成抑制剂。Terrein 诱导乳腺癌细胞凋亡 (apoptosis)。Terrein是铜绿假单胞菌 (Pseudomonas aeruginosa) 中的群体感应和 c-di-GMP 抑制剂。 靶点/IC50 Melanocortin Receptor; Apoptosis; Antibiotic 体外研究 Illudin M (0.01-10μM; 24-120 hours) shows cytotoxicity and induction of apoptosis in vitroTreatment of Mel-Ab cells with Terrein (10-100µM) for 4 days significantly reduces melanin levels in a dose-dependent manner. Terrein reduces melanin synthesis by reducing tyrosinase production via ERK activation.Terrein (5-500µM; 24 and 48 hours) reduces the viability of these cells in concentration- and time-dependent manners.Terrein (150, 250, 500µM; 24 hours) induces programmed cell death in both invasive and non-invasive breast cancer cell lines. Thus, the optimal non-toxic concentrations of Terrein (25 and 75µM) were used for subsequent experiments.Terrein (25 and 75µM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MDA-MB-231 cells. Terrein (75µM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MCF-7 cells.Terrein (75µM) inhibits the expression of RhoA, RhoB, p-Rac1 in MCF-7 cells. Terrein (75µM) inhibits the expression of RhoB,p-Rac1 in MDA-MB-231 cells.Terrein (10, 30, and 100μM) inhibits the production of virulence factors such as elastase, pyocyanin, and rhamnolipid, as well as biofilm formation in P. aeruginosa PAO1 and PA14 strains. Cell Viability Assay Cell Line: MCF-7 and MDA-MB-231 cells Concentration: 5, 25, 50, 75, 100, 150, 250, 500µM Incubation Time: 24 and 48 hours Result: The IC50s for MCF-7 and MDA-MB-231 cells after 24 h of incubation were 2.34mM and 700µM, respectively. After 48h of incubation, the IC50s are 244.3µM for MCF-7 and 244.5µM for MDA-MB-231 cells. Apoptosis Analysis Cell Line: MCF-7 and MDA-MB-231 cells Concentration: 25, 75, 150, 250, 500µM Incubation Time: 24 hours Result: The percentages of apoptotic cells after 25 and 75µM treatment were 7.52 and 5.82%,respectively for MCF-7 cells (9.94% for the control), and 15.77 and 15.82%,respectively for MDA-MB-231 cells (8.79% for the control). RT-PCR Cell Line: MCF-7 and MDA-MB-231 cells Concentration: 25, 75µM Incubation Time:   Result: Decreased the mRNA levels of both MMP-2 and MMP-9 in a concentration-dependent manner. Western Blot Analysis Cell Line: MCF-7 and MDA-MB-231 cells Concentration: 75µM Incubation Time: 6, 12 and 24 hours Result: RhoA and RhoB protein levels were significantly decreased after 6h of 75µM treatment in MCF-7 cells. Phosphorylated (p)-Rac1 was also slightly decreased at 12h.However, RhoC and Cdc42 levels remained unchanged. RhoB protein levels and Rac1 phosphorylation were also decreased in MDA-MB-231 cells at 12 and 24h,respectively.
保存条件：-20℃

猜你喜欢