DCVC ≥98%
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| 包装规格: | 1mg 5mg 10mg in glass bottle |
| 产品简介: | 一种三氯乙烯 (TCE) 的生物活性代谢产物。DCVC 可抑制病原体刺激的组织培养物中促炎细胞因子 IL-1β,IL-8 和 TNF-α 的释放。 |
| 溶解性: | 溶于DMSO(2.5 mg/mL 超声) |
| 储备液保存: | -80°C, 2 years -20°C, 1 year |
| 体外研究: | Extraplacental membranes are cultured for 4, 8, and 24h with the trichloroethylene (TCE) metabolite S-(1,2-dichlorovinyl)-l-cysteine (DCVC) in the absence or presence of lipoteichoic acid (LTA) or lipopolysaccharide (LPS) to simulate infection. In addition, membranes were cocultured with DCVC and Group B Streptococcus (GBS). DCVC (5-50μM) significantly inhibited LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4h. DCVC inhibits pathogen-stimulated cytokine (IL-1β, IL-8, and TNF-α) release in a concentration-dependent manner. |
| 产品描述: | 基本信息 产品编号:D10787 产品名称:DCVC CAS: 13419-46-0 储存条件 粉末 -20℃ 四年 分子式: C5H7Cl2NO2S 溶于液体 -80℃ 六个月 分子量 216.09 -20℃ 一个月 化学名: Solubility (25°C) 体外 DMSO Ethanol Water 体内(现配现用) <1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 制备储备液 浓度 溶液体积 质量 1mg 5mg 10mg 1mM 4.6277mL 23.1385mL 46.2770mL 5mM 0.9255mL 4.6277mL 9.2554mL 10mM 0.4628mL 2.3139mL 4.6277mL 生物活性 产品描述 一种三氯乙烯 (TCE) 的生物活性代谢产物。DCVC 可抑制病原体刺激的组织培养物中促炎细胞因子 IL-1β,IL-8 和 TNF-α 的释放。 靶点/IC50 TNF Receptor 体外研究 Extraplacental membranes are cultured for 4, 8, and 24h with the trichloroethylene (TCE) metabolite S-(1,2-dichlorovinyl)-lcysteine (DCVC) in the absence or presence of lipoteichoic acid (LTA) or lipopolysaccharide (LPS) to simulate infection. In addition,membranes were cocultured with DCVC and Group B Streptococcus (GBS). DCVC (5-50μM) significantly inhibited LTA-,LPS-,and GBS-stimulated cytokine release from tissue cultures as early as 4h. DCVC inhibits pathogen-stimulated cytokine (IL-1β, IL-8, and TNF-α) release in a concentration-dependent manner. |
| 保存条件: | -20℃ |
| 注意事项: | 1、为了您的安全和健康,请穿实验服并戴一次性手套操作。 2、以上信息仅做参考交流之用。 |
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