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硫蒽酮  ≥98%

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包装规格：1mg 5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO(25 mg/mL 超声）
产品描述：基本信息 产品编号：L10365 产品名称：Lucanthone CAS: 479-50-5   储存条件 粉末 -20℃ 四年     分子式： C20H24N2Os 溶于液体 -80℃ 两年 分子量 340.48 -20℃ 一个月 化学名：  1-{[2-(Diethylamino)ethyl]amino}-4-methyl-9H-thioxanthen-9-one   Solubility (25°C)   体外 DMSO 33mg/mL (96.92mM) Ethanol 68mg/mL (199.71mM) Water Insoluble 体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.9370mL 14.6852mL 29.3703mL 5mM 0.5874mL 2.9370mL 5.8741mL 10mM 0.2937mL 1.4685mL 2.9370mL 50mM 0.0587mL 0.2937mL 0.5874mL   生物活性 产品描述 一种Apurinic 内切核酸酶-1 (APE-1) 的内切核酸酶抑制剂。 靶点/IC50 APE-1   体外研究 Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone, cell viability is measured by MTT assay. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC50 of 7.2μM versus 66μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results.   推荐实验方法(仅供参考) 细胞实验:   Cell Assay Cell viability is assessed by MTT assay. Cells are seeded into 96-well microculture plates at 10,000 cells per well and allowed to attach for 24 h. Cells are then treated with Lucanthone (0, 0.5, 1, 5, 10, 20 and 40μM), Chloroquine, Vorinostat, or combinations for 72 h. Following drug treatment, MTT is added and cell viability is quantified using a BioTek microplate reader. Effects on cell viability are also determined by measuring ATP levels using the ATPlite assay system and by trypan blue exclusion. Pro-apoptotic effects following in vitro drug exposure are quantified by propidium iodide (PI) staining and fluorescence-activated cell sorting (FACS) analysis of sub-G0/G1 DNA content.
保存条件：-20℃

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