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C2 神经酰胺 促销  ≥98%

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包装规格：5mg 25mg in glass bottle
产品简介：一种角质层的主要脂质，也是一种蛋白质磷酸酶 1 (PP1) 的激活剂。
溶解性：DMSO：20 mg/mL (58.56 mM; 超声加热助溶) Ethanol：25 mg/mL (73.20 mM; 超声加热助溶)
储备液保存：-80°C, 6 months-20°C, 1 month (sealed storage, away from moisture)。
靶点：Protein phosphatase 1 PP2A Ceramide-activated protein phosphatase (CAPP) Apoptosis Mitochondrial respiratory chain complex III
体外研究：C2 Ceramide (5 nM-200 μM; 24 hours; primary mouse osteoblasts) treatment (≤500 nM) promotsosteoblast viability, whilst concentrations ≥2 μM significantly reduces osteoblast viabilityin a dose- and time-dependent manner. C2 Ceramide increases cytoplasmic histone-associated DNA fragments by 5.7- and 11.2-fold at50 μM and 100 μM C2 Ceramide concentrations respectively in osteoblasts. At these higherconcentrations, C2 Ceramide is a potent inducer of apoptosis in osteoblasts. C2 Ceramide up-regulates mRNA expression of angiogenic genes in human dental pulp cells(HDPCs) and increases the migration and capillary tube formation of endothelial cells, whereasPP1 small interfering RNA shows opposite effects. Human dental pulp cells (HDPCs) increaseslevels of bone morphogenetic protein 2, phosphorylation of Smad 1/5/8, and mRNA expressionof runt-related transcription factor 2 and osterix.
体内研究：The PP1 activator C2 Ceramide increases alkaline phosphatase activity, mineralizes noduleformation, and mRNA expression of dentin matrix protein 1 and dentin sialophosphoprotein.In contrast, knockdown by PP1 small interfering RNA inhibits odontoblastic differentiation.
保存条件：-20℃
注意事项：1、为了您的安全和健康，请穿实验服并戴一次性手套操作。 2、以上信息仅做参考交流之用。

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