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硝酸奥昔康唑  ≥98%

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包装规格：5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO（≥ 100 mg/mL） -20°C 10mg 50mg 100mg in glass bottle
产品描述：基本信息 产品编号：O10166 产品名称：Oxiconazole nitrate CAS: 64211-46-7   储存条件 粉末 -20℃ 四年     分子式： C18H14Cl4N4O4 溶于液体 -80℃ 六个月 分子量 492.14 -20℃ 一个月 化学名：  Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-,O-[(2,4-dichlorophenyl)methyl]oxime, (1Z)-, mononitrate   Solubility (25°C)   体外 DMSO ≥100mg/mL (203.19mM) Ethanol   Water   体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.0319mL 10.1597mL 20.3194mL 5mM 0.4064mL 2.0319mL 4.0639mL 10mM 0.2032mL 1.0160mL 2.0319mL   生物活性 产品描述 一种广谱抗真菌药物，可以抑制 T. tonsurans 和 T.rubrum 的生长 靶点/IC50 T. tonsurans MIC90: 0.25μg/mL T. rubrum 0.5μg/mL   体外研究 Oxiconazole nitrate is the more active compound in tests with T. tonsurans and T. rubrum. Twelve isolates are inhibited by 0.063 μg/mL of oxiconazole; corresponding econazole MICs range from 0.063 (three isolates) to 8 (two isolates)μg/mL. Three isolates have oxiconazole MICs of 16 or 32μg/mL.   体内研究 The baseline distortion product otoacoustic emission (DPOAE) results of the right ears of all animals tested are normal.Animals in groups I, II, IV and V show no statistically significant change in the DPOAE amplitudes. The rats in the gentamicingroup show a significant decrease.   推荐实验方法(仅供参考) 细胞实验:   Cell Assay A total of 121 isolates of pathogenic fungi are tested. The three drugs (including Oxiconazole nitrate) are serially diluted in sterile saline. For each test plate, 2mL of a solution of drug in sterile saline is added to an 18mL blank of molten agar medium at 50°C and mixed well; the resulting mixtures are then poured into the plates and allowed to solidify. The resulting drug dilution sequences range from 128 to 0.063μg/mL. Control plates are prepared in a similar manner using 2mL blanks of sterile saline. The plates are then inoculated using a replicator. Incubation is at 30°C for a minimum of 96 hr. The Minimal Inhibitory Concentration (MIC) is defined as the lowest concentration of drug producing complete inhibition of growth.   动物实验:   Animal Administration Fifty adult rats are divided into 5 groups consisting of 10 animals each. Over 14days, the rats in group I receive 0.1mL of Oxiconazole nitrate-containing solution drops, group II receives 4% boric acid solution in alcohol drops, and groups III and IV receive gentamicin (40mg/mL) and saline solutions, respectively. Group V receives no medication. Each solution used is given twice a day.
保存条件：-20℃

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