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GKT137831  ≥98%

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包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO( ≥10mg/mL )
产品描述：一种选择性的NADPH氧化酶(NOX1/4)抑制剂。GKT137831 is a novel and potent Nox4 inhibitor. GKT137831 reduced the increased leukocyte adherence to the vasculature, the pro-inflammatory phenotype of microglia and macroglia, the increased gene and protein expression of vascular endothelial growth factor, monocyte chemoattractant protein-1, and leukocyte adhesion molecules as well as vascular leakage. In all cultured cell types, GKT137831 reduced the hypoxia-induced increase in ROS levels and protein expression of various inflammatory mediators. GKT137831 may be potentially useful as a treatment for a variety of vision-threatening retinopathies.
保存条件：-20℃

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