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美加明 盐酸盐  ≥98%

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包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于水(≥40mg/mL)、乙醇和甘油。
产品描述：基本信息 产品编号： M60014 产品名称： Mecamylamine hydrochloride CAS: 826-39-1   储存条件 粉末 2-8℃ 四年 分子式： C11H21N.HCl 溶于液体 -80℃(密封储存，防潮) 6个月 分子量： 203.75 -20℃(密封储存，防潮) 1个月 化学名：  Inversine;N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 4.9080mL 24.5399mL 49.0798mL 5mM 0.9816mL 4.9080mL 9.8160mL 10mM 0.4908mL 2.4540mL 4.9080mL   生物活性 产品描述 一种一种nAChR拮抗剂。 靶点 nAChR   体外研究 Mecamylamine blocks muscle nAChRs in a use-and voltagedependent manner.Mecamylamine blocks the nicotinic currents via trapping mechanism.The main feature of this block is the phenomenon of block relief,which might be revealed by combined action of depolarization and activation of nAChRs.The experimental study of the Mecamylamine action on muscle nAChRs revealed that:(1) Mecamylamine (1-20μM) reduces evoked end-plate currents (EPC) amplitude with Hill’s constant equal to 1.2 and IC50=7.8μM at holding potential–70 mV;(2) the calculated depth of its interaction with the muscle nAChR channel is almost half of the one of neuronal nAChRs (0.37 compare to 0.72 for neuronal nAChRs);(3) simultaneous membrane depolarization and repetitive activation of postsynaptic nAChRs by motor nerve stimulation produced rapid block relief dependent on the degree of depolarization,number of conditioning signals and Mecamylamine concentration,and only slightly depended on the rate of stimulation. 体内研究 Mecamylamine (0.5-1mg/kg;Intraperitoneal injection;C57BL/6J mice) has antidepressant-like effects in both the TST and FST and these effects are dependent on bothβ2 andα7 subunits. Animal Model: C57BL/6J mice (3-4 months) forced swim test (FST) and tail suspension test (TST) Dosage: 0.5mg/kg,0.75mg/kg,1mg/kg Administration: Intraperitoneal injection Result: Significantly decreased immobility time in the TST at the 1.0-mg/kg dose but did not alter baseline locomotor activity.Also significantly decreased time immobile in the FST.
保存条件：2-8℃

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