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GTPL5846  ≥98%(HPLC)

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包装规格：1mg 5mg 10mg 25mg 50mg in glass bottle
产品简介：一种GPR84激动剂，在PI assay中EC50值为105nM。
溶解性：溶于DMSO(25mg/mL 超声)
储备液保存：-80°C, 2 years -20°C, 1 year
靶点：ERK
体外研究：GPR84 gene exhibits high expression in human polymorphonuclear leukocytes (PMNs) and macrophages, 6-OAU acts on proinflammatory function by activitating GPR84. 6-OAU (0.01 nM-0.1 mM; 1 h) activates human GPR84 in the presence of Gqi5 chimera with an EC50 value of 105 nM in HEK293 cells. 6-OAU (0, 6.25, 200 μM; 30 min) stimulates [35S]GTP binding, accumulates phosphoinositides, and induces GPR84-EGFP internalization in a GPR84-dependent manner. 6-OAU (1 nM-1 mM; 1 h) provokes chemotaxis of PMNs in a concentration-dependent manner with an EC50 value of 318 nM. 6-OAU (0-10 μM; 4 h) increases the secretion of IL-8 from LPS-stimulated PMNs. 6-OAU (0-0.4 μM; 16 h) also amplifies TNF-α production from U937 macrophages. 6-OAU (2 μM; 4 h) decreases ERK phosphorylation and MCP-1 protein expression, (2 μM; 48 h) decreases MCP-1 secretion in macrophages. 6-OAU (2 μM; 24 h) reduces ROS production during B. abortus infection in RAW264.7 cells. 6-OAU (2 μM; 0, 30, and 60 min) inhibits adhesion and Brucella uptake in RAW264.7 cells and (2 μM; 30 min) shows anti-infection against Brucella and Salmonella infection.
体内研究：6-OAU activates GPR84 and results in making an inflammatory condition through chemokine production and chemotaxis in vivo. 6-OAU (10 mg/kg; i.v.) raises the blood CXCL1 level in rats. 6-OAU (1 mg/mL; s.c.) attracts both PMNs and macrophages into the air pouch. 6-OAU (2 μM, 100 mL/mouse; s.c.) augments resistance to Brucella infection, and reduces bacterial proliferation in spleens and livers.
保存条件：-20℃
注意事项：1、为了您的安全和健康，请穿实验服并戴一次性手套操作。 2、以上信息仅做参考交流之用。

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