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甲异靛  ≥98%(HPLC)

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包装规格：5mg 25mg 100mg 250mg 1g in glass bottle
溶解性：溶于DMSO(≥50mg/mL)
产品描述：基本信息 产品编号：M10320 产品名称：Meisoindigo CAS: 97207-47-1   储存条件 粉末 -20℃ 四年     分子式： C18H14N2O2 溶于液体 -80℃ 六个月 分子量 290.31 -20℃ 一个月 化学名：      Solubility (25°C)   体外 DMSO 55mg/mL (199.06mM) Ethanol 1mg/mL (3.61mM) Water Insoluble 体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.6194mL 18.0969mL 36.1939mL 5mM 0.7239mL 3.6194mL 7.2388mL 10mM 0.3619mL 1.8097mL 3.6194mL 50mM 0.0724mL 0.3619mL 0.7239mL   生物活性 产品描述 一种可诱导急性髓性白血病的凋亡和髓样分化的化合物。 靶点/IC50 Apoptosis   体外研究 Meisoindigo (Dian III; 5-20μM; for 24 hours) inhibits growth of the AML cell lines.Meisoindigo (10μM; for 24 hours) induces apoptosis of acute myeloid leukemia.Meisoindigo (5-10μM; for 24hours) causes cell-cycle arrest.Meisoindigo (5-10μM; for 24 hours) increases the cleaved caspase-3 and pro-apoptotic Bak, and decreases Bcl-2 and Bcl-xL levels in HL-60 cells.Meisoindigo (10, 30, 50, 100, 150μM; 24 hours) interdicts LPS-induced (1μg/mL) NLRP3 inflammasome activation and M1/M2 polarization through down-regulation of TLR4 pathways after OGD/R in HT-22 and BV2 cells. Cell Viability Assay Cell Line: HL-60, NB4, U937 leukemic cell lines Concentration: 5, 10, 15, 20μM Incubation Time: For 24 hours Result: Inhibited growth of the AML cell lines in a dose- and time-dependent manner. Apoptosis Analysis Cell Line: HL-60 cells Concentration: 10μM Incubation Time: For 24 hours Result: Induced apoptosis of acute myeloid leukemia. Cell Cycle Analysis Cell Line: HL-60 cells Concentration: 5, 10μM Incubation Time: For 24 hours Result: Caused cell-cycle arrest, with more cells in sub-G1 and G0/G1 phases and fewer cells in the S phase, in a dose-dependent manner. Western Blot Analysis Cell Line: HL-60 cells Concentration: 5, 10μM Incubation Time: For 24 hours Result: Increased the cleaved caspase-3 and pro-apoptotic Bak, and decreased Bcl-2 and Bcl-xL levels in HL-60 cells. 体内研究 Meisoindigo (Dian III; 50-150mg/kg; IP; daily; for 14 days) has anti-leukemic activity in vivo.Meisoindigo (2, 4, 8, 12mg/kg; IP; before MCAO and 2h after reperfusion) significantly reduces infarct volume, ameliorates neurological deficits 3 days after middle cerebral artery occlusion (MCAO) in Wild-type C57BL/6J mice (25-30g).Meisoindigo reduces edema and lowers AQP4 expression in the brain. Animal Model: NOD/SCID mice, 6-8 weeks old, with HL-60 leukemic cells Dosage: 50, 100, 150mg/kg Administration: IP; daily; for 14 days Result: Had anti-leukemic activity in vivo.
保存条件：-20℃

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