Debio 0932 ≥98%(HPLC)
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| 包装规格: | 1mg 5mg 25mg 100mg in glass bottle |
| 溶解性: | 溶于DMSO(≥33mg/mL) |
| 产品描述: | 一种HSP90(热休克蛋白90)抑制剂,对 HSP90α和 HSP90β的IC50值分别为100和103nM。Debio 0932 is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance. |
| 保存条件: | -20℃ |
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