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SB 431542 hydrate 促销  ≥98% (HPLC)

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包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO(10 mg/mL )和乙醇(45 mg/ml）
产品描述：一种转化生长因子 β 受体 (TGF-β Receptor) 抑制剂和有效的ALK5 抑制剂,TGFβ RII: IC50 = 66 nM (human); TGFβ RI: IC50 = 94 nM; ACTR-IB: IC50 = 140 nM。SB 431542 is a small molecule that acts as a specific and selective inhibitor of TGFβ RI, ACTR-IB and ACTR-IC (transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, 5, and 7). Renal carcinoma studies have demonstrated that SB 431542 is a selective inhibitor of Smad3 phosphorylation (IC50= 94nM) and TGF-β-1 collagen induced lα1 (col Iα1). It has been reported that SB 431542 does not affect the JNK, ERK, or p38 MAP kinase pathways. SB 431542 has been shown to suppress TGF-β induced growth stimulation in MG63 cells, inhibit the motility and proliferation of glioma cells, and block the phosphorylation and translocation of SMADs.
保存条件：-20℃

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