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MK-1775 促销  99.262%(HPLC)

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包装规格：10mg 50mg 100mg in glass bottle
溶解性：溶于DMSO(80mg/mL)
产品描述：一种WEE1抑制剂，IC50：5.2nM，具有潜在的抗肿瘤增敏活性。 MK-1775 is a WEE1 inhibitor, is also a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents。
保存条件：-20℃

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