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SU9516  ≥98%(HPLC)

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包装规格：2mg 5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于 DMSO (10 mg/ml)和乙醇(20 mM)。
产品描述：一种强力的有选择性的周期蛋白依赖性激酶（CDKs）抑制剂。SU9516 is a 3-substituted indolinone compound displaying anti-proliferative and proapoptotic properties in tumor cells. SU9516 displays activity as a selectively potent ATP-competitive inhibitor of CDKs. It also shows no significant effect (IC50 >10 μM) on the activities of PKC, p38, PDGFRβ, or EGFR. SU9516 has an Inhibitory effect on proliferation of growth-factor stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F. SU9516 is an inhibitor of Cdc2, Cdk2 and Cdk4.
保存条件：2-8℃

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