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包装规格：5mg 10mg 25mg 50mg 100mg in glass bottle
产品简介：一种有效的口服黄嘌呤氧化还原酶 (XOR) 抑制剂，IC50 值为 5.3 nM，Ki 值为 5.7 nM。Topiroxostat 还表现出弱的 CYP3A4 抑制活性 (18.6%)。Topiroxostat 有潜力用于高尿酸血症的研究。
溶解性：DMSO :23.5 mg/mL (94.67 mM; 超声加热助溶)
储备液保存：-80°C, 2 years -20°C, 1 year
靶点：IC50: 5.3 nM (XOR) Ki: 5.7 nM (XOR)
体外研究：These potent and more sustained effects of Topiroxostat (FYX-051, compound 39) have been confirmed by a crystallographic analysis of XOR-Topiroxostat complex. The cyano group of Topiroxostat has been reported to play an important role in the binding activity between Topiroxostat and XOR. This is attributable to the formation of a hydrogen bond between Asn 768 of XOR and the cyano group of Topiroxostat.
体内研究：Topiroxostat (FYX-051; 0.03-10 mg/kg; oral administration; for 1 hour; male Wistar/ST strain rats) treatment shows a potent and long-lasting hypouricemic effect in a rat model of potassium oxonate-induced hyperuricemia. The Cmax and bioavailability of Topiroxostat (FYX-051, compound 39) are as high as 4.62 μg/mL (3 mg/kg) and 69.6%, respectively. Moreover, the t1/2 value of Topiroxostat is 19.7 hours.
保存条件：-20°C
注意事项：1、为了您的安全和健康，请穿实验服并戴一次性手套操作。 2、以上信息仅做参考交流之用。

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