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丙咪嗪盐酸盐  ≥98%

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包装规格：1g 5g in glass bottle
溶解性：溶于DMSO(≥100mg/mL）
产品描述：基本信息 产品编号： I20014 产品名称： Imipramine hydrochloride CAS: 113-52-0   储存条件 粉末 室温 四年     分子式： C19H24N2.HCl 溶于液体 -80℃ 六个月 分子量 316.87 -20℃ 一个月 化学名：  3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;hydrochloride Solubility (25°C)：   体外:   DMSO 63 mg/mL (198.81mM) Ethanol 63 mg/mL (198.81mM) Water 63 mg/mL (198.81mM) 体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.1559mL 15.7793mL 31.5587mL 5mM 0.6312mL 3.1559mL 6.3117mL 10mM 0.3156mL 1.5779mL 3.1559mL 50mM 0.0631mL 0.3156mL 0.6312mL   生物活性 产品描述 抑制血清素转运蛋白(serotonin)，IC50 值为 32nM。Imipramine hydrochloride 可阻止胰酶的易位，抑制 MV 和外泌体的分泌。 靶点 IC50: 32nM (serotonin)   体外研究 Depression-like behavior is often complicated by chronic pain. Antidepressants including imipramine are widely used to treat chronic pain, but the mechanisms are not fully understood. Imipramine (IC50=32nM) and desipramine (IC50=160nM) are found to be potent inhibitors of the human placental serotonin transporter. 体内研究 Administration of imipramine reverses social avoidance behavior, significantly increasing the interaction time. 24 days of imipramine treatment in RSD mice significantly decreases stress-induced mRNA levels for IL-6 in brain microglia. Chronic mild stress induces a long-term altered gene expression profile in the prefrontal cortex that is partially reverted by imipramine treatment (10mg/kg, i.p.). Chronic imipramine administration alteres the amino acid dynamics in the brain. In the striatum, the concentrations of asparagine, glutamine and methionine are significantly increased by chronic imipramine administration. In the thalamus and hypothalamus, chronic imipramine administration significantly decreased the valine concentration. Imipramine reduces pain-related negative emotion without influencing pain and that this effect is diminished by denervation of 5-HT neurons and by anti-BDNF treatment. Imipramine also normalizes derangement of ERK/CREB coupling, which leads to induction of BDNF. This suggests a possible interaction between 5-HT and BDNF. Imipramine treatment counteracts the corticosterone administration-induced increase in the reactivity of rat CA3 hippocampal circuitry to the activation of the 5-HT receptor . 特征     推荐实验方法(仅供参考) 细胞实验：   Animal Administration Rats: The Wistar (WIS) and Wistar Kyoto (WKY) rats are divided into four groups: (1) a control WIS rat group, (2) an imipramine-treated WIS rat group, (3) a control WKY rat group and (4) an imipramine-treated WKY rat group. Distilled water (10 mL/kg) or imipramine solution (10 mg/10 mL/kg) is orally administered for 28 days except on the day of the open field test, when nothing is administered in order to avoid the acute effect of single administration on the open field test[5] . Mice: C57BL/6 mice subjected to repeated social defeat (RSD), home cage control (HCC) are randomLy selected into four groups: RSD/imipramine, RSD/vehicle, HCC/imipramine, and HCC/vehicle. Mice in the RSD/imipramine received daily intraperitoneal (i.p.) injections of imipramine (20mg/kg) for 24 days after the 6 cycles of RSD. HCC/imipramine received daily i.p. imipramine at the same dose while RSD/vehicle and HCC/vehicle groups received i.p. injections of vehicle (sodium chloride, 0.9%) for 24 days at the same time point.
保存条件：室温

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