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tBID  

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溶解性：溶于DMSO（26mg/mL超声）
产品描述：基本信息 产品编号：T11327 产品名称：tBID CAS: 1639895-85-4   储存条件 粉末 -20℃ 四年     分子式： C11H3Br4N3O2 溶于液体 -80℃ 六个月 分子量 528.78 -20℃ 一个月 化学名：      Solubility (25°C)   体外 DMSO   Ethanol   Water   体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 1.8911mL 9.4557mL 18.9115mL 5mM 0.3782mL 1.8911mL 3.7823mL 10mM 0.1891mL 0.9456mL 1.8911mL   生物活性 产品描述 一种同源结构域相互作用蛋白激酶2 (HIPK2) 的选择性抑制剂，IC50值为 0.33μM。 靶点/IC50 IC50: 0.33µM (HIPK2) 体外研究 Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival. TBID,displays toward HIPK2 unprecedented efficacy (IC50=0.33µM) and selectivity (Gini coefficient 0.592 out of a panel of 76 kinases).The two other members of the HIPK family, HIPK1 and HIPK3, are also inhibited by TBID albeit less efficiently than HIPK2. The mode of action of TBID is competitive with respect to ATP, consistent with modelling. TBID interacts with the hinge region through hydrophobic interactions between Val 213, Val 261, Phe 277, Leu 280, Met 331, Ile 345, and the tetrabromine moiety, while the symmetric nitrogen atom at position 3 interacts with the catalytic Lys 228, thus playing a crucial role in the binding architecture.   推荐实验方法(仅供参考) 细胞实验:   HepG2 cells (human hepatocellular carcinoma) are cultured in Dulbecco's modified Eagle's medium supplemented with 10% fetal calf serum, 2 mM L-glutamine, 100unit/mL penicillin and 100µg/mL streptomycin. Treatments with TBID are performed in the same medium but with 1% fetal calf serum; control cells are treated with the solvent (DMSO). Cell viability is evaluated by means of MTT.
保存条件：-20℃

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