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AhR modulator-1  

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产品描述：基本信息 产品编号： A12645 产品名称： AhR modulator-1 CAS: 115039-00-4   储存条件 粉末 -20℃ 四年     分子式： C13H7Cl3O 溶于液体     分子量 285.55     化学名：  6-methyl 1,3,8-trichlorodibenzofuran   生物活性 产品描述 一种选择性的口服活性芳烃受体 (AhR) 调节剂。AhR modulator-1 部分地通过在肿瘤形成之前抑制前列腺 VEGF 的产生而抑制肿瘤转移。AhR modulator-1 在大鼠子宫中也具有抗雌激素特性。 靶点 Aryl hydrocarbon receptor (AhR) Prostatic VEGF Estrogenic 体外研究 AhR modulator-1 (6-MCDF; 0.1-10μM; 48-96 hours; ASPC-1 cells) treatment exhibits dose-dependent growth inhibitory effects with growth inhibitory effects of 26, 43 and 99% at concentrations of 0.1, 1 and 10μM, respectively Cell Proliferation Assay Cell Line: ASPC-1 cells Concentration: 0.1μM, 1μM and 10μM Incubation Time: 48 hours, 72 hours, 96 hours Result: Exhibited dose-dependent growth inhibitory effects. 体内研究 AhR modulator-1 (6-MCDF; 0-40mg/kg; oral administration; daily; for 12 weeks; C57BL/6-Tg(TRAMP)8247Ng/J mice) treatment reduces the frequency of pelvic lymph node metastasis in mice fed the 40mg/kg diet. And serum VEGF concentrations are also reduced. Prostate tumor incidence and size are not significantly reduced Animal Model: C57BL/6-Tg(TRAMP)8247Ng/J (TRAMP) mice (8-week-old) Dosage: 0mg/kg, 10mg/kg, 40mg/kg Administration: Oral administration; daily; for 12 weeks Result: The frequency of pelvic lymph node metastasis was reduced 5-fold in mice fed the 40mg /kg diet.S erum VEGF concentrations were also reduced.
保存条件：-20℃

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