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NS-1619  ≥98%

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包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO(5mg/ml)
产品描述：基本信息 产品编号： N11046 产品名称： NS-1619 CAS: 153587-01-0   储存条件 粉末 -20℃ 四年     分子式： C15H8F6N2O2 溶于液体 -80℃ 6个月 分子量： 362.23 -20℃ 1个月 化学名：  1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one Solubility (25°C)：   体外:   DMSO 72mg/mL (198.76mM) Ethanol 72mg/mL (198.76mM) Water ˂1mg/mL 体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.7607mL 13.8034mL 27.6068mL 5mM 0.5521mL 2.7607mL 5.5214mL 10mM 0.2761mL 1.3803mL 2.7607mL   生物活性 产品描述 一种选择性的Ca2+-activatedK+通道激动剂。 靶点 Potassium Channel Apoptosis   体外研究 NS1619 (5,10,30,50,and 100μM) inhibits the proliferation of A2780 cells in a dosage and time dependent manner IC50=31.1μM for 48h pretreatment.NS1619 (30μM) exhibits augmenting effect on whole cell IK in human ovarian cancer cells A2780.NS1619 (10,30,50,and 100μM) increases levels of p53,p21Cip1 and Bax proteins in A2780 cells.DNA content of A2780 cells was significantly decreased after 36 and 48h of pretreatment.The breakdown of DNA results in death of the tumor cells. Cell Viability Assay Cell Line: The human ovarian cancer cell line A2780 Concentration: 5,10,30,50,and 100μM Incubation Time: 48 hours Result: Inhibited cell growth in a time and concentration-dependent manner,IC50=31.1μM.Proliferation was significantly inhibited at concentrations of NS1619 higher than 10μM. Western Blot Analysis Cell Line: A2780 cells Concentration: 0,5,10,30,50,and 100μM Incubation Time: 48 hours Result: Expression of p53,p21,and Bax in A2780 cells was significantly increased in comparison with control. Western Blot Analysis Cell Line: A2780 cells Concentration: 30μM Incubation Time: 36 and 48 hours Result: DNA content of A2780 cells was significantly decreased after 36 and 48h of pretreatment.The breakdown of DNA results in death of the tumor cells. 体内研究 Opening of KCa channels with NS-1619 (1mg/kg;i.p.) can delay protection in mouse hearts. Animal Model: Adult male outbred ICR mice Dosage: 1mg/kg Administration: Pretreated i.p.24h before I/R Result: Pretreatment induced delayed protection 24h later.Resulted in significant cardioprotection 24h later,i.e.,infarct size was reduced from 38.8±3.7% to 19.8±2.9%.
保存条件：-20℃

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