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Nicainoprol  ≥98%

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包装规格：5mg in glass bottle
溶解性：溶于DMSO(≥29mg/ml)
产品描述：基本信息 产品编号： N11059 产品名称： Nicainoprol CAS: 76252-06-7   储存条件 粉末 -20℃ 四年     分子式： C21H27N3O3 溶于液体 -80℃ 6个月 分子量： 369.46 -20℃ 1个月 化学名：  1,2,3,4-TETRAHYDRO-8-[2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY]-1-(3-PYRIDYLCARBONYL)QUINOLINE Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.7067mL 13.5333mL 27.0665mL 5mM 0.5413mL 2.7067mL 5.4133mL 10mM 0.2707mL 1.3533mL 2.7067mL   生物活性 产品描述 一种快速钠通道(sodium-channel)阻断剂，是一种有效的抗心律失常剂。 靶点 Sodium Channel   体外研究 The antiarrhythmic agent Nicainoprol,a fast-sodium-channel blocking drug,also protected isolated rat hearts against reperfusion arrhythmias,but is without beneficial effects on cardiac hemodynamics and biochemical parameters,in contrast to the ACE inhibitor. 体内研究 The effect of the novel antiarrhythmic agent Nicainoprol on coronary occlusion and reperfusion arrhythmia is investigated in isolated working rat hearts and in anesthetized rats.In isolated working rat hearts Nicainoprol (10μM,5μM and 100μM) induces concentration-related protection against reperfusion arrhythmia without changing the cardiodynamics,with the exception of a decrease in heart rate at the highest concentration.Enzyme levels (lactate dehydrogenase and creatine kinase) in the coronary venous effluent,and cardiac tissue concentrations of glycogen,lactate,ATP and creatine phosphate are not affected by Nicainoprol.Given to anesthetized rats,Nicainoprol (5 and 10mg/kg i.v.) reduces dose dependently in the early post occlusion (0-30 min) period, the percentage of animals with premature ventricular complexes (PVCs) and ventricular tachycardia while completely preventing the occurrence of ventricular fibrillation.In the reperfusion period no animal treated with 5mg/kg and 12% of the rats treated with 10mg/kg showed PVCs (the only form of arrhythmia observed in this period) versus 60% of the control rats.Both doses of Nicainoprol induces a decrease in heart rate,blood pressure and myocardial oxygen consumption.The ratio of infarct mass to ventricular mass is significantly reduced by 20% at a dose of 5mg/kg and by 28% at the dose of 10mg/kg.Nicainoprol could be useful in the prevention and treatment of arrhythmias associated with acute myocardial infarction.
保存条件：-20℃

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