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喹夫拉朋钠  ≥98%

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包装规格：1mg 5mg 10mg 50mg in glass bottle
溶解性：溶于DMSO（50 mg/mL 超声）
产品描述：基本信息 产品编号：Q10042 产品名称：Quiflapon sodium CAS: 147030-01-1   储存条件 粉末 -20℃ 四年     分子式： C34H34ClN2NaO3S 溶于液体 -80℃ 六个月 分子量 609.15 -20℃ 一个月 化学名：      Solubility (25°C)   体外 DMSO   Ethanol   Water   体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 1.6416mL 8.2082mL 16.4163mL 5mM 0.3283mL 1.6416mL 3.2833mL 10mM 0.1642mL 0.8208mL 1.6416mL   生物活性 产品描述 一种有效的，具有口服活性的白三烯生物合成 (leukotriene biosynthesis) 抑制剂。诱导细胞凋亡 (apoptosis)。 靶点/IC50 FLAP Apoptosis   体外研究 Quiflapon sodium (MK591) and SB203580 are able to block SEB-induced human PBMC cell proliferation. Quiflapon sodium (MK591) down regulates three genes [for cathepsin L, IL-17 and guanylate binding protein (GBP)-2] that are up regulated by SEB. Quiflapon sodium (MK591) undergoes apoptosis within hours of treatment.Quiflapon sodium also induces rapid activation of the stress kinase, c-Jun N-terminal kinase (JNK), which plays an important role in the apoptosis process.Quiflapon sodium triggers apoptosis in prostate cancer cells without inhibition of PI3K-Akt, or ERK. Moreover, Quiflapon sodium and LY294002 exert synergistic effect in inducing apoptosis in prostate cancer cells. Quiflapon sodium (MK591) influences cAMP response element-binding protein but not Sp1. 体内研究 Hyperoxia groups of mice treated with Quiflapon sodium (MK591) (20, 40mg/kg) show alveolarization that resembles that of room air controls while untreated hyperoxia groups show definite evidence of aberrant alveolarization but no inflammation. Comparison of the Aβ-immunopositive areas between the placebo and Quiflapon sodium (MK591) (320mg/kg)-treated group reveals a statistically significant reduction of the amyloid burden in the treated mice. Quiflapon sodium also has a significant reduction in brain levels of IL-1β. Mice treated with Quiflapon sodium show a statistically significant decrease in the steady-state levels of total CREB and its phosphorylated form at Ser133.   推荐实验方法(仅供参考)   动物实验:   The Tg2576 transgenic mice expressing human APP with the Swedish mutation (K670N/M671L) are used in these studies.They are genotyped by PCR analysis using tail DNA and kept in a pathogen-free environment, on a 12-hour light/dark cycle and have access to food and water ad libitum. All the experiments presented in this paper are performed with female mice.Starting at 7 months of age, mice are randomized to receive Quiflapon sodium (40mg/kg weight) (n=11) or vehicle (n=9) in their chow diet for 8 months until they are 15 months old. Considering that each mouse eats on average 5 g/day of chow diet and the diet is formulated for 320mg Quiflapon sodium per kg diet, the final dose of the active drug is approximately 40mg/kg weight/day. During the study, mice in both groups gain weight regularly, and no significant difference in weight is detected between the two groups. No macroscopic effect on the overall general health is observed in the animals receiving the active treatment. Post-mortem examination shows no sign of macroscopic pathology in any of the organs considered (spleen, liver, thymus, ileum).
保存条件：-20℃

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