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Pentosan Polysulfate  ≥98%

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包装规格：100mg in glass bottle
产品描述：基本信息 产品编号：P10628 产品名称：Pentosan Polysulfate CAS: 37300-21-3   储存条件 粉末 -20℃ 四年 分子式： C10H18O21S4 分子量 602.50 化学名：  [(2R,3R,4S,5R)-2-hydroxy-5-[(2S,3R,4S,5R)-5-hydroxy-3,4-disulfooxyoxan-2-yl]oxy-3-sulfooxyoxan-4-yl] hydrogen sulfate   Solubility (25°C)   体外 DMSO < 1mg/mL (insoluble or slightly soluble) Ethanol   Water < 1mg/mL (insoluble or slightly soluble) 体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种口服有效的半合成药物，具有抗炎和促软骨生成的特性。 靶点/IC50 HIV   体外研究 Pentosan polysulfate has been shown to inhibit HIV-1 activity with an ED50 of 0.19μg/mL in MT-4 cells. It inhibits HIV-1antigen expression in HUT-78 cells at an ED50 of 0.02μg/mL, and complete inhibition of HIV-1 antigen expression is obtainedat a concentration of 4.0μg/mL.Pentosan Polysulfate suppresses NF-κB, decreases the proinflammatory actions of TNFα, and decreases high glucose andadvanced glycation end products (AGEs) stimulated MCP-1 production.   体内研究 Pentosan polysulfate has been shown to decreases interstitial inflammation andglomerulosclerosis in 5/6 nephrectomizedrats. Pentosan polysulfate treatment preserves renal function, significantly reduces albuminuria, and markedly decreasesthe severity of renal lesions, includingtubulointerstitial inflammation. Pentosan polysulfate also reduces upregulation ofTNFα and proinflammatory genes in aging diabetic kidneys. 特征     推荐实验方法(仅供参考) 细胞实验:   Cell Assay MT-4 and HUT-78 cells are cultured in microtray wells in the presence of pentosan polysulfate (0-2500μg/mL) addedimmediately after infection with 100 CCIDs0 of HIV-1 (CCIDs0 being the 50% cell culture infective dose). After 5 daysincubation at 37°C, the number of viable ceils is determined by the 3'-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) method.   动物实验:   Animal Administration Mice with stable hyperglycemia at 18months of age are selected for the study. Eighteen-month-old diabetic mice arerandomly divided into pentosan polysulfate-treated (25mg/kg/day in the drinking water) and control groups. Diabetic miceare followed for 4months without insulin treatment. Mouse is housed individually and water intake is recorded every otherday. Body weight and blood glucose levels are monitored weekly. Additionally, urine ketones are examined. Urine albumiexcretion is measured bi-weekly. One-month-old MPS VI rats are given once weekly sc injections of Pentosan Polysulfate (1,2 and 4mg/kg, human equivalentdose (HED)), or daily oral Pentosan Polysulfate (4mg/kg HED) for 6 months. Serum inflammatory markers and totalglycosaminoglycans(GAGs) are measured, as are several histological, morphological and functional endpoints.
保存条件：-20℃

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