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N-羟基胞苷  ≥98%

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包装规格：1mg 5mg 10mg 25mg 50mg in glass bottle
溶解性：溶于DMSO
产品描述：基本信息 产品编号：N10186 产品名称：β-d-N4-hydroxycytidine CAS: 3258-02-4   储存条件 粉末 -20℃ 四年 分子式： C9H13N3O6 溶于液体 -80℃ 两年 分子量 259.22     化学名：  1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one   Solubility (25°C)   体外 DMSO   Ethanol 3mg/mL (11.57mM) Water 15mg/mL (57.86mM) 体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.8577mL 19.2886mL 38.5773mL 5mM 0.7715mL 3.8577mL 7.7155mL 10mM 0.3858mL 1.9289mL 3.8577mL 50mM 0.0772mL 0.3858mL 0.7715mL   生物活性 产品描述 一种有效的抗委内瑞拉马脑炎病毒剂。 靶点/IC50 SARS-CoV Enterovirus HCV Topoisomerase   体外研究 Beta-d-N4-hydroxycytidine is an anti-VEEV (venezuelan equine encephalitis virus) agent with EC50, EC90, and EC99 are 0.426,1.036, and 2.5μM, respectively. Beta-d-N4-hydroxycytidine inhibits CHIKV replicon activity and the 50% effective concentration (EC50) s 0.8μM in the Huh7–CHIKV replicon cell line. Similar results is presented with the replicon in BHK-21 cells (EC50=1.8μM). NHC has no cytotoxicity for NHC in the Huh-7 cell culture system until up to 100μM using MTT assays. The 50% cytotoxic concentration (CCsub>50) values for NHC are determined to be 30.6μM, 7.7μM, and 2.5μM in peripheral blood mononuclear(PBM), Vero, and CEM cells, respectively. NHC behaves as a pyrimidine analog, NHC-mediated inhibition of the CHIKV replicon can be abrogated by the addition of exogenous nucleosides, such as pyrimidines C and U, but dA, dC, dG, dU, or T has no impact on the replicon. Pyrimidines A and G contributes to replicon inhibition both in the presence and in the absence of NHC.
保存条件：-20℃
注意事项：该产品在溶液状态不稳定，建议您现用现配.

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