生物试剂
>
生化试剂
>
信号通路
> TB5
加入收藏 取消收藏

TB5  ≥95%

促销价¥{{model.attbuying.price}}

市场价¥0.00

累计销量0 累计评价0 人评论

别称 {{model.alias}}
中文名称 {{model.name}}
英文名称 {{model.enname}}
品牌 {{model.brand}}
CAS {{model.cas}}
分子式
分子量 {{model.molecularweight}}
MDL {{model.mdl}}
货号 {{model.procode}}
数量

+ -

件 库存{{model.attbuying.number}}件
立即购买 加入购物车 下载说明书

看了又看
包装规格：5mg 25mg 100mg in glass bottle
产品描述：基本信息 产品编号： T11464  产品名称： TB5 CAS: 948841-07-4   储存条件 粉末 -20℃ 四年     分子式： C15H14BrNOs 溶于液体 -80℃ 两年 分子量 336.25 -20℃ 1个月 化学名：  (E)-1-(5-Bromothiophen-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one Solubility (25°C)：   体外:   DMSO 67 mg/mL (199.25mM) Ethanol 2 mg/mL (5.94mM) Water Insoluble 体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.9740mL 14.8699mL 29.7398mL 5mM 0.5948mL 2.9740mL 5.9480mL 10mM 0.2974mL 1.4870mL 2.9740mL 50mM 0.0595mL 0.2974mL 0.5948mL   生物活性 产品描述 一种具有有效性，选择性和可逆性的 hMAO-B 抑制剂，Ki 值为 0.11±0.01μM。 靶点 MAO-B () 110nM(Ki) 体外研究 TB5 and TB8 interacts with the catalytic site of hMAO-B and hMAO-A with a competitive mode of inhibition. TB5 shows the best inhibitory activity and higher selectivity toward hMAO-B, with Ki and SI values of 0.11±0.01μM and 13.18, respectively. hMAO-B inhibition by compound TB5 and hMAO-A inhibition by compound TB8 are completely reversed after 24 h of dialysis. Cytotoxicity studies show TB5 is nontoxic at 5 and 25μM, resulting in cell viabilities of 95.75% and 84.59 %, respectively. 体内研究 Compounds are dissolved in DMSO (5 mg/mL) and diluted with PBS/EtOH (70:30).Kinetic analyses are carried out for TB5 and TB8. A set of Lineweaver–Burk plots are constructed in the absence and presence of various concentrations of compounds TB5 and TC8. The set consists of five graphs, each constructed by measuring MAO-B and MAO-A catalytic rates at different substrate concentrations (0.1-1μM). The first Lineweaver–Burk plot is constructed in the absence of inhibitor, while the remaining four graphs are constructed in the presence of different concentrations of TB5 and TB8.   推荐实验方法(仅供参考) Kinase Assay Compounds are dissolved in DMSO (5 mg/mL) and diluted with PBS/EtOH (70:30).Kinetic analyses are carried out for TB5 and TB8. A set of Lineweaver–Burk plots are constructed in the absence and presence of various concentrations of compounds TB5 and TC8. The set consists of five graphs, each constructed by measuring MAO-B and MAO-A catalytic rates at different substrate concentrations (0.1-1μM). The first Lineweaver–Burk plot is constructed in the absence of inhibitor, while the remaining four graphs are constructed in the presence of different concentrations of TB5 and TB8   Cell Assay In vitro cytotoxicity of brominated thiophene chalcones and standard MAO inhibitors are tested in human HepG2 hepatic cancer cells at three different concentrations (1, 5 and 25μM).
保存条件：-20℃

猜你喜欢