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Xanomeline oxalate  ≥98%

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包装规格：5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO(≥50mg/mL）
产品描述：基本信息 产品编号：X10074 产品名称：Xanomeline oxalate CAS: 141064-23-5   储存条件 粉末 -20℃ 四年     分子式： C16H25N3O5S 溶于液体 -80℃ 六个月 分子量： 371.45 -20℃ 一个月 化学名：      Solubility (25°C)   体外 DMSO   Ethanol   Water   体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.6922mL 13.4608mL 26.9215mL 5mM 0.5384mL 2.6922mL 5.3843mL 10mM 0.2692mL 1.3461mL 2.6922mL   生物活性 产品描述 一种有效的、选择性毒蕈碱受体激动剂 (SMRA)，可刺激体内的磷酸肌醇水解。Xanomeline oxalate 可用于研究阿尔茨海默氏病。 靶点/IC50 muscarinic receptor   体外研究 Xanomeline stimulates phosphoinositide (PI) hydrolysis in the A9 L m1 cells.Xanomeline inhibits [3H]-pirenzepine ([3H]-PZ) and [3H]-oxotremorine-M ([3H]-OXO-M) binding to rat brain with Kis of 7 and 3nM, respectively. 体内研究 Xanomeline robustly stimulates in vivo PI hydrolysis and the effect is blocked by muscarinic antagonists,demonstrating mediation by muscarinic receptors.In mice the ED100 for Xanomeline-induced stimulation of [3H]-IP accumulation is 54μmole/kg in hippocampus.And in rats the ED100 for Xanomeline-induced stimulation of [3H]-IP accumulation is 8.1μmole/kg in hippocampus. Animal Model: Male CF1 mice weighing 18-20g are injected [3H]-myoinositol. Dosage: 8.1-81μmole/kg Administration: S.c.injections;1h prior to killing and 1h after the administration. Result: Increased accumulation in a dose-related manner up to 130%,75%,60% above lithium levels in hippocampus,cortex and neostriatum,respectively.And did not increase accumulation of [3H]-IP in the brain stem.Induced salivation,tremor and hypothermia in mice with the ED50 of 13.7±0.8μmole/kg.   Animal Model: Rats are injected [3H]-myoinositol Dosage: 2.7-81μmole/kg Administration: S.c.injections;1h prior to killing and 1h after the administration. Result: Increased [3H]-IP formation dose dependently in hippocampus up to 221% above lithium control.
保存条件：-20℃

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