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BMS453  ≥98%

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包装规格：5mg in glass bottle
产品描述：基本信息 产品编号： B11377 产品名称： BMS453 CAS: 166977-43-1   储存条件 粉末 -20℃ 四年     分子式： C27H24O2 溶于液体 -80℃ 六个月 分子量 380.48 -20℃ 一个月 化学名：  (E)-4-[2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid 生物活性 产品描述 一种合成类维生素 A，是一种 RARβ 激动剂和 RARα/RARγ 拮抗剂。BMS453 主要通过诱导活性 TGFβ 来抑制乳腺细胞生长。 靶点   体外研究 BMS453 (1μM; 11 hours; 184 and HMEC cells) treatment inhibits the proliferation of normal breast cell growth without significantly inducing apoptosis. BMS453 (1μM; 5 days; 184 and HMEC cells) treatment inhibits normal breast cell proliferation by causing G1 arrest. BMS453 (1μM; 24-72 hours; 184 cells) treatment induces Rb hypophosphorylation and decrease CDK2 kinase activity. BMS453 increases total p21 protein levels and CDK2-bound p21 protein, but does not change CDK4-bound p21. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ Cell Proliferation Assay Cell Line: Normal human mammary epithelial cells (184 and HMEC) Concentration: 1μM Incubation Time: 11 hours Result: Inhibited 3H-thymidine uptake in normal breast cells (184 and HMEC) by 40 %. Cell Cycle Analysis Cell Line: Normal human mammary epithelial cells (184 and HMEC) Concentration: 1μM Incubation Time: 5 days Result: Increased the proportion of cells in G0/G1 phase and decreased the proportion of cells in S phase. Western Blot Analysis Cell Line: 184 cells Concentration: 1μM Incubation Time: 24 hours, 48 hours, 72 hours Result: Induced Rb hypophosphorylation and decrease CDK2 kinase activity.
保存条件：-20℃

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