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包装规格：1mg in glass bottle
产品描述：基本信息 产品编号： T10853 产品名称： Tarazepide CAS: 141374-81-4   储存条件 粉末 -20℃ 四年 分子式： C28H24N4O2 溶于液体 -80℃ 二年 分子量 448.52     化学名：  N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-1-azatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraene-2-carboxamide Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 生物活性 产品描述 一种有效且特异性的 CCK-A 受体拮抗剂。 靶点 CCK-A receptor 体内研究 Tarazepide decreases duodenal electric activity,reduces interdigestive pancreatic secretion,especially protein;reduces cephalic and early postprandial (milk) induced secretion of bicarbonate and protein.Pancreatic protein secretion to intravenous CCK-8 was little affected by atropine,but was significantly reduced by Tarazepide±Atropine;in contrast, protein secretion to intraduodenal CCK-8 was abolished by Tarazepide or atropine.Leptin is administered to the animals at doses of 0.1,1.0 or 10.0μg/kg i.d.Tarazepide (2.5mg/kg,i.d.),a CCK(1) receptor antagonist,is given to the rats prior to the application of leptin.CCK plasma level is measured by radioimmunoassay (RIA) following administration of leptin to the rats.Intraduodenal administration of leptin (1.0 or 10.0 microg/kg) to the fasted rats significantly and dose-dependently increases pancreatic protein and amylase outputs.Pancreatic secretory responses to leptin were totally abolished by prior capsaicin deactivation of sensory nerves or by pretreatment of the rats with Tarazepide. 推荐实验方法(仅供参考) 动物实验:   Calve The 5 to 7-day-old Friesian male calves (42.0±1.5kg body weight) are used.The study is made on four calves.After recording 2 to 3 preprandial (interdigestive) MMC/PPS cycles,Tarazepide suspension (0.05,0.5 and 5.0mg/kg body weight),or vehicle alone (1% methylcellulose) is infused intraduodenally (i.d.).
保存条件：-20℃

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